[The hydrochloride salt form of sibutramine, a phenethylamine derivative with appetite depressant property. Sibutramine hydrochloride metabolites M1 and M2 competitively inhibit the reuptake of norepinephrine, serotonin, and to a lesser degree dopamine by pre-synaptic nerve terminals, thereby promoting a sense of satiety, leading to a decrease in calorie intake, and possibly an increase in resting metabolic rate. This agent does not exhibit anticholinergic or antihistaminic effects. ( NCI )]
UMLS (NCI) C0142278 - Organic Chemical
- Pharmacologic Substance
Relation/PAR: sibutramine
Relation/CHD: SIBUTRAMINE HYDROCHLORIDE 15 MG
SIBUTRAMINE HYDROCHLORIDE 10 MG
SIBUTRAMINE HYDROCHLORIDE 5 MG