[Encoded by human oncogene WISP3 Gene (CCN Family), the 354-amino acid 39.3 kD WNT1 Inducible Signaling Pathway Protein 3 constitutes - with WISP1 and WISP2 - one of three factors downstream in the WNT signaling pathway relevant to malignant transformation. CCN proteins are cell- and tissue-specific cysteine-rich secreted factors with roles in cell growth and differentiation. WISP3 protein is essential for skeletal growth and cartilage homeostasis; mutations are associated with progressive pseudorheumatoid dysplasia. WISP3 is over expressed in colon tumors. (OMIM, Swiss-Prot, LocusLink, and NCI) ( NCI )]
UMLS (NCI) C1309276WISP3
WISP3 Protein
WNT1 Inducible Signaling Pathway Protein 3
- Amino Acid, Peptide, or Protein
- Biologically Active Substance