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UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
%
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
C C- C1 C3 C5 C6 C7 CA CB CC CD CE CF CG CH CI CJ CK CL CM CN CO CP CQ CR CS CT CU CV CW CX CY CZ
CA CA CA1 CA2 CA4 CAA CAB CAC CAD CAE CAF CAG CAH CAI CAL CAM CAN CAO CAP CAR CAS CAT CAU CAV CAY

Cadherin-1

[Encoded by human CDH1 Gene (CDH Family), 882-amino acid 97 kD (precursor) invasion suppressor type I membrane protein E-Cadherin is the main homodimeric Ca(2+)-dependent cell-cell adhesion glycoprotein in non-neural epithelia. Structurally similar to immunoglobulins, E-cadherin contains five extracellular cadherin repeats, a transmembrane region, and a conserved cytoplasmic tail required for internalization. E-Cadherin acts as ligand for integrin Alpha-E/Beta-7. CDH1 defects cause Familial Gastric Cancer. CDH1 mutations are correlated with breast, colorectal, thyroid, and ovarian cancer. E-cadherin down regulation often correlates with invasive potential and poor prognosis of human carcinomas; it is likely a main event in cancer proliferation, invasion, and metastasis, due to dysfunction of cell-cell adhesion. (from LocusLink, SWISS-PROT, OMIM, and NCI) ( NCI )]
UMLS (NCI) C0042172
 
Amino Acid, Peptide, or Protein
Biologically Active Substance

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