[Cytokine Inducible SH2-Containing Protein, encoded by the human CISH gene, is a cytokine-inducible negative regulator of cytokine signaling. This protein contains a SH2 domain and a SOCS box domain. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein is involved in the inactivation of the erythropoietin receptor. Association with EPOR may target this protein for proteolysis by the ubiquitin-dependent proteasome pathway. The CISH protein is mainly monoubiquitinated (37 kD) but may also exist in a polyubiquitinated form (45 kD). Three isoforms (1, 1B, 1C) are produced by alternative splicing, and the tissue distribution of isoforms 1 and 1B is distinct. (From LocusLink, Swiss-Prot and NCI) ( NCI )]
UMLS (NCI) C0299250 - Amino Acid, Peptide, or Protein
- Biologically Active Substance
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