[Widely expressed by human NCOA5 Gene, 579-aa 66-kDa Nuclear Receptor Coactivator 5 contains an LXXLL motif essential for association with nuclear receptors and acts as a coregulator for ESR1, ESR2, and orphan nuclear receptor NR1D2. NCOA5 interacts with ESR1 and ESR2 independently of the steroid binding AF2 domain that regulates interaction with other coreceptors. NCOA5 exerts both coactivator and corepressor functions. (NCI) ( NCI )]
UMLS (NCI) C1367655Coactivator Independent of AF2
NCOA5
Nuclear Receptor Coactivator 5
- Amino Acid, Peptide, or Protein
- Biologically Active Substance