CDK2AP1

1. [CDK2-Associated Protein 1, encoded by the CDK2AP1 gene, is a specific CDK2-associated protein that negatively regulates CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein also interacts with DNA polymerase alpha/primase and promotes the phosphorylation of the large p180 subunit, which suggests the regulatory role in DNA replication during S phase of the cell cycle. Reduction of CDK2AP1 protein expression is a frequent event in oral cancers and is a negative prognostic indicator in patients with surgically resected oral squamous cell carcinoma. Loss of CDK2AP1 protein expression may contribute to the multistep nature of oral carcinogenesis. (From LocusLink, PubMed and NCI) ( NCI )]
   UMLS (NCI) C1332731
   
   CDK2-Associated Protein 1
   CDKAP1
   Cyclin-Dependent Kinase 2-Associated Protein 1
   Deleted in Oral Cancer 1
   Deleted In Oral Cancer-1
   DOC1
   DOC-1
    

   Amino Acid, Peptide, or Protein

   Biologically Active Substance

2. [This gene is involved in cell cycle regulation. ( NCI )]
   UMLS (NCI) C1332732
   
   CDK2AP1 Gene
   CDK2-Associated Protein 1 Gene
   
    

   Gene or Genome