CDC45

[CDC45-Related Protein, encoded by the CDC45L gene, was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. CDC45-Related Protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggest that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. (from LocusLink) ( NCI )]

UMLS (NCI) C0755538

CDC45 (Cell Division Cycle 45, S. cerevisiae, Homolog)-Like
CDC45 Cell Division Cycle 45-Like (S. cerevisiae)
CDC45L
CDC45L2
CDC45-Like
CDC45-Related Protein
Cell Division Cycle 45, S. cerevisiae, Homolog-Like
Cell Division Cycle 45-Like 2
PORC-PI-1

Amino Acid, Peptide, or Protein
Biologically Active Substance

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