[CD97 Antigen, encoded by the CD97 gene, is a founding member of the EGF-TM7 family of class II seven-span transmembrane (7-TM) molecules. CD97 Antigen is a glycoprotein present on the surface of most activated leukocytes and is a G protein-coupled receptor. This protein has an extended extracellular region with several N-terminal epidermal growth factor (EGF)-like domains, which mediate binding to its cellular ligand, decay accelerating factor (DAF, CD55), a regulatory protein of the complement cascade. The presence of structural features characteristic of extracellular matrix proteins and transmembrane proteins suggests that this protein is a receptor involved in both cell adhesion and signaling processes early after leukocyte activation. Alternative splicing generates two variants. CD97 Antigen has large N-terminal domain with five epidermal growth factor-like sequences which are differentially spliced. (From LocusLink and NCI) ( NCI )]
UMLS (NCI) C0300533 - Amino Acid, Peptide, or Protein
- Immunologic Factor
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