[Expressed in monocytes, macrophages, neutrophils, eosinophils, platelets, NK cells, and T- and B-lymphocytes by human FCGR2A Gene, 281-aa (mature) IgG Fc Receptor IIA is a type I cell surface membrane protein with 2 extracellular IgC2 domains and a low affinity receptor for aggregated IgG Fc region. FCGR2A binding to IgG initiates essential effector and regulatory cellular responses against foreign pathogens and soluble antigens that induce phagocytosis of antigen-antibody complexes, removing them from circulation, and modulate B-cell antibody production. An Arg167His polymorphism affects efficiency of IgG2 recognition. (NCI) ( NCI )]
UMLS (NCI) C1448238Fc-Gamma-RIIA
CD32
FCG2
Fc-Gamma RIIA
FcGR
FCGR2
FCGR2A
FCGR2A1
FcRIIA
IGFR2
IgG Fc Receptor IIA
Low Affinity IgG Fc Fragment Receptor IIA
Low Affinity Immunoglobulin Gamma Fc Region Receptor IIA
- Amino Acid, Peptide, or Protein
- Receptor