[Expressed in monocytes, lymphocytes, and placenta by human IFNGR1 Gene (Type II Cytokine Receptor Family), monomeric 489-aa 90-kDa type I membrane protein Interferon Gamma Receptor Alpha Chain is a subunit of Ser/Thr phosphorylated heteromeric Interferon Gamma Receptor Complex, composed of IFNGR1 and IFNGR2, that activates macrophages in host defenses. Containing an N-terminal signal peptide, 7 potential N-linked glycosylation sites, several potential Ser- and Thr-rich O-linked glycosylation sites, 2 fibronectin type III domains, 2 Ig-like C2-type domains, a transmembrane domain, and a cytoplasmic portion, IFNGR1 acts as the receptor ligand-binding subunit. IFNGR2 constitutes an integral receptor accessory factor required for signal transduction. Defects in IFNGR1 are a cause of FDAMI. (NCI) ( NCI )]
UMLS (NCI) C1334195CD119 Antigen
CDw119
IFN-Gamma-R1
Immune Interferon Receptor
Interferon Gamma Receptor Alpha Chain
Interferon Gamma Receptor-1
- Amino Acid, Peptide, or Protein
- Receptor