[Part of the heterodimeric transcription factor Core-Binding Factor. CBF beta does not bind to DNA directly, but increases the affinity and stabilizes the binding of the CBF alpha (transcription factor AML1) for the CBF enhancer/promoter DNA site in TCR genes. CBF appears to regulate hematopoietic differentiation. Disruption of CBFB is associated with some leukemias. (from SWISS-PROT Q13951, OMIM 121360, and NCI) ( NCI )]
UMLS (NCI) C0526211 - Amino Acid, Peptide, or Protein
- Biologically Active Substance