UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
%
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
B B B0 B1 B4 B7 B8 BA BB BC BD BE BF BG BH BI BK BL BM BN BO BP BR BS BT BU BV BW BX BY BZ
BE BE+ BEA BEB BEC BED BEE BEF BEG BEH BEI BEK BEL BEM BEN BEP BER BES BET BEU BEV BEX

Becaplermin

[Expressed as 2 alternative isoforms in platelets by human PDGFB Gene (PDGF/VEGF Family), 241-aa 27-kDa (precursor) Platelet-Derived Growth Factor-Beta Chain is a potent mitogenic factor for mesenchymal cells characterized by a motif of eight cysteines and released by platelets upon wounding to stimulate adjacent cell growth. PDGFB can exist as either antiparallel disulfide-linked homodimers or heterodimers with Platelet-Derived Growth Factor Alpha. A-A, B-B, and A-B, dimers can bind to PDGF receptor and elicit a variety of cellular responses. A and B homodimers are implicated in transformation processes. PDGFB mutations are associated with meningioma. Reciprocal t(17;22)(q22;q13) translocations with COL1A1 result in unregulated growth factor expression and are associated with DFSP. (NCI) ( NCI )]
UMLS (NCI) C0072480
 
Amino Acid, Peptide, or Protein
Biologically Active Substance


 home Dictionaries Armenian-English English-Armenian MeSH Feedback  top
© 2008 -2011 Administrator MEDINDEX.AM