- 1. Besnier Boeck disease
- [inflammatory disease characterized by small lumps or granulomas in lymph nodes and other organs. ( CSP )] (UMLS (CSP) C0036202) =Disease or Syndrome ;
=Lymphoproliferative Disorder;
immunopathology =Lung Sarcoidosis;
Uveoparotid Fever | - 2. BESpm
- [A synthetic bis-ethyl analogue of spermine with potential antineoplastic activity. N(1),N(11)-bis(ethyl)norspermine (DENSPM), a N-terminally alkylated tetraamine and polyamine mimetic, disrupts polyamine pool homeostasis by modulating the activities of the biosynthetic enzymes, ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (AdoMetDC). This agent also reduces polyamine concentrations through the induction of the catabolic enzyme spermidine/spermine N1-acetyltransferase 1 (SSAT). Polyamines, an integral part of the DNA helix structure, play a critical role in cell division, differentiation and membrane function. Disruption of normal polyamine concentrations by DENSPM may lead to cell growth inhibition. ( NCI )] (UMLS (NCI) C0067116) =Organic Chemical; Pharmacologic Substance ;
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