B Double Prime

[Encoded by human PR48 Gene (PP2A Regulatory Subunit B Family), 414-aa nuclear Protein Phosphatase 2A 48kDa Regulatory Subunit is a B regulatory subunit of PP2A. PR48 specifically interacts with the N-terminal region of and dephosphorylates CDC6, modulating initiation of DNA replication and cell cycle control. A major heterotrimeric Ser/Thr phosphatase implicated in negative control of many cellular processes including cell growth and division, PP2A core enzyme consists of a 36-kDa catalytic C subunit and a constant 65-kDa regulatory/structural A subunit that interact with either a B regulatory subunit or with cell signaling molecules, that likely modulate substrate selectivity, catalytic activity, and subcellular localization, yielding the trimeric holoenzyme. Combinations of different subunit isoforms can generate many forms of PP2A that may differ in substrate specificity, subcellular location, or tissue specific expression. (NCI) ( NCI )]

UMLS (NCI) C1335537

NY-REN-8
NY-REN-8 Antigen
PP2A B Double Prime Subunit PR48
PP2A Subunit B PR48 Isoform
PR48
Protein Phosphatase-2A-48kDa Regulatory Subunit
Serine/Threonine Protein Phosphatase 2A 48kDa Regulatory Subunit
Serine/Threonine Protein Phosphatase 2A 48kDa Regulatory Subunit B

Amino Acid, Peptide, or Protein
Enzyme

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