[Secreted by tumor cells, autocrine motility factor stimulates tumor motility. Its glycoprotein receptor, Autocrine Mobility Factor Receptor, has some homology to p53. In normal fibroblasts, receptor expression appears to be regulated by cell-cell contact. The level of expression is associated with the pathologic stage and grade of tumor penetration. Positive AMFR expression on tumor cells correlates with poor prognosis in bladder cancer. (from OMIM 603243 and NCI) ( NCI )]
UMLS (NCI) C0147219 - Amino Acid, Peptide, or Protein
- Receptor