- 1. A-myb Messenger RNA Overexpression
- (UMLS (NCI) C1510675) A-myb mRNA Overexpression;
=Cell or Molecular Dysfunction ;
| - 15. Amyloid Beta Precursor Protein (Cytoplasmic Tail) Binding Protein 2 Gene
- [This gene plays a role in the regulation of protein transport and microtubule dynamics. The gene has also been implicated in the pathogenesis of Alzheimer's disease. ( NCI )] (UMLS (NCI) C1332104) APPBP2;
APPBP2 Gene =Gene or Genome ;
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- 2. AMYB
- [A DNA-binding, transcriptional activator with a possible role in proliferation and/or differentiation of neurogenic, spermatogenic and B-lymphoid cells. A-Myb specifically recognizes the DNA sequence 5'-YAAC(G/T)G-3' and belongs to the Myb family. (from SWISS-PROT P10243, OMIM 159405, and NCI) ( NCI )] (UMLS (NCI) C0258050) =Amino Acid, Peptide, or Protein; Biologically Active Substance
| - 16. Amyloid Beta-Peptide Pathway
- [Alzheimer's disease is associated with dense aggregations of proteins in the brain called amyloid plaques that contain beta-amyloid fragments as a primary component. If the development of amyloid plaques is responsible for neurodegeneration in Alzheimer's disease, reduction of beta-amyloid formation may prevent the development and progression of disease symptoms. Beta-amyloid fragments are derived from proteolytic processing of amyloid precursor protein (APP) in neurons, and the subsequent release of fragments into the extracellular space. APP in the ER is cleaved at residue 17 by alpha-secretase protease activity encoded by ADAM-10 and TACE. Beta-secretase activity, recently identified as BACE, cleaves in the N-terminus of the beta-amyloid fragment. Gamma-secretase cuts APP within the transmembrane domain at amino acids 40 and 42, releasing the beta-amyloid fragment containing residues 1-40/42 as well as shorter products such as p3 (residues 17-40/42) that requires alpha-secretase cleavage. The gamma-secretase activity requires the transmembrane protein Presenilin-1 that is itself cleaved into an N-terminal and C-terminal fragment that both are required for gamma-secretase activity. Mutations in presenilin-1 have been genetically associated with familial forms of Alzheimer's disease, further supporting the role of APP processing the development of the disease. Inhibition of the beta- or gamma-secretases may provide a mechanism to treat this disease. Other mechanisms may include altering degradation of beta-amyloid, and the use of vaccines against beta-amyloid to remove aggregates. (BioCarta) ( NCI )] (UMLS (NCI) C1510880) Generation of amyloid b-peptide by PS1;
=Molecular Function ;
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- 3. amygdala
- [almond-shaped group of basal nuclei anterior to the inferior horn of the lateral ventricle of the brain, within the temporal lobe; part of the limbic system. ( CSP )] (UMLS (CSP) C0002708) =Body Part, Organ, or Organ Component
| - 17. amyloid disease
- [any disease manifested by the pathogenic accumulation of amyloid in organs and tissues. ( CSP )] (UMLS (CSP) C0002726) =Disease or Syndrome
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- 4. Amygdalin
- [A cyanogenic glucoside isolated from almonds and seeds of other plants of the family Rosaceae. Amygdalin is converted by plant emulsin (a combination of a glucosidase and a nitrilase) or hydrochloric acid into benzaldehyde, D-glucose, and hydrocyanic acid. (NCI04) ( NCI )] (UMLS (NCI) C0002707) =Carbohydrate; Pharmacologic Substance ;
| - 18. Amyloid Fibril Interaction
- [Amyloid Fibril Interaction involves temporary non-covalent binding of a molecule through intermolecular physical forces of attraction with insoluble forms of a secretase-processed metal ion-binding type I cell surface glycoprotein (APP Family) required for endocytosis and BaSS sorting; important in developing synapses, for cell mobility, adhesion, and axonogenesis; and Notch signaling inhibitor, copper homeostasis regulator, transcription activator, and apoptosis enhancer. ( NCI )] (UMLS (NCI) C1510881) =Molecular Function ;
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- 5. amyl nitrite
- [A vasodilator that is administered by inhalation. It is also used recreationally due to its supposed ability to induce euphoria and act as an aphrodisiac. ( MSH )] (UMLS (CSP) C0002711) =Organic Chemical; Pharmacologic Substance ;
| - 19. amyloid precursor protein
- [A precursor to the AMYLOID-BETA PROTEIN (beta/A4). Alterations in the expression of the amyloid beta-protein precursor (ABPP) gene, located on chromosome 21, plays a role in the development of the neuropathology common to both ALZHEIMER DISEASE and DOWN SYNDROME. ABPP is associated with the extensive extracellular matrix secreted by neuronal cells. Upon cleavage, this precursor produces three proteins of varying amino acid lengths: 695, 751, and 770. The beta/A4 (695 amino acids) or beta-amyloid protein is the principal component of the extracellular amyloid in senile plaques found in ALZHEIMER DISEASE; DOWN SYNDROME and, to a limited extent, in normal aging. ( MSH )] (UMLS (CSP) C0085151) =Amino Acid, Peptide, or Protein ;
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- 6. amylase
- [(AM-il-aze) An enzyme that helps the body digest starches. ( NCI )] (UMLS (CSP) C0002712) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Enzyme
| - 20. Amyloid Precursor Protein Secretase
- [Cathepsin B, encoded by the CTSB Gene, encodes a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of Cathepsin B has been associated with esophageal adenocarcinoma and other tumors. Tumors with overexpression of cathepsins have powerful potential for invasiveness in the early stage of gastric carcinoma. Gastric carcinoma cells that oversecrete cathepsins B have a high invasive and metastatic potential. At least five transcript variants encoding the same protein have been found for this gene. (From LocusLink, PMID 10931446 and NCI) ( NCI )] (UMLS (NCI) C0699919) =Amino Acid, Peptide, or Protein; Enzyme =caspase;
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- 7. Amylase
- [A measurement of the pancreatic enzyme amylase in a biological specimen. ( NCI )] (UMLS (NCI) C0201883) =Laboratory Procedure
| - 21. amyloid protein
- [extracellular glycoprotein that accumulates in certain pathological conditions, e.g., the paired helical filaments of neuritic plaques in Alzheimer's disease and Down's syndrome; use this term for both the precursor and beta form. ( CSP )] (UMLS (CSP) C1456454) =Amino Acid, Peptide, or Protein; Biologically Active Substance =glycoprotein;
fibrous protein |
- 8. amylase inhibitor
- [ ] (UMLS (CSP) C0597832) =Pharmacologic Substance =enzyme inhibitor;
| - 22. Amyloid Resorption Induction
- [Amyloid Resorption Induction involves initiation of activities of involved in the breakdown and assimilation of amyloid deposits. ( NCI )] (UMLS (NCI) C1510882) =Molecular Function ;
|
- 9. amylin
- [37-amino acid polypeptide occurring packaged with insulin in the beta cell secretory granules in normal pancreatic islets; also, a major component of islet amyloid in patients with noninsulin dependent diabetes mellitus. ( CSP )] (UMLS (CSP) C0063684) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Hormone =Interacinar Cell Pancreatic Polypeptide;
| - 23. Amyloidoma
- [Amyloidoma - nodular localized form of amyloidosis with predominantly thoracic localization (pulmonary amyloidosis), considered as secondary protein structure diseases in which insoluble protein fibrils accumulate extracellularly. The form of primary amyloid in amyloidoma is characterized by abnormal deposition of light chain proteins composed of monoclonal immunoglobulin. Pulmonary amyloidomas are rare and are often found incidentally as solitary or multiple calcified nodules and masses on chest radiographs in asymptomatic elderly patients. Cavitation is rare, the prognosis is good. ( NCI )] (UMLS (NCI) C0544840) =Neoplastic Process
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- 10. amylo 1,4:1,6 transglucosidase deficiency
- [ ] (UMLS (CSP) C0677581) =Disease or Syndrome
| - 24. AMYLOIDOSIS NEC
- [ ] (UMLS (ICD9CM) C0348499) =Disease or Syndrome
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- 11. amylo 1,6 glucosidase
- [ ] (UMLS (CSP) C0051775) =Amino Acid, Peptide, or Protein; Enzyme
| - 25. amylopectinosis
- [autosomal recessive metabolic disorder due to a deficiency in expression of branching enzyme (alpha-1,4-glucan-6-alpha-glucosyltransferase), resulting in an accumulation of abnormal glycogen with long outer branches; clinical features are muscle hypotonia and cirrhosis; death from liver disease usually occurs before age 2. ( CSP )] (UMLS (CSP) C0017923) =Disease or Syndrome =glycogen storage disease;
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- 12. amylo 1,6 glucosidase deficiency
- [autosomal recessive metabolic disorder due to deficient expression of amylo-1,6-glucosidase; clinical course is similar to that of glycogen storage disease type I, but milder; massive hepatomegaly, which is present in young children, diminishes and occasionally disappears with age; levels of glycogen with short outer branches are elevated in muscle, liver, and erythrocytes. ( CSP )] (UMLS (CSP) C0017922) =Disease or Syndrome =glycogen storage disease;
| - 26. amylophosphorylase
- [mobilizes glucose-1-phosphate from glycogen in muscle and other tissues do not use as a general term to cover other phosphorylases (see PHOSPHOTRANSFERASE). ( CSP )] (UMLS (CSP) C0917783) muscle phosphorylase;
phosphorylase;
polyphosphorylase;
=Amino Acid, Peptide, or Protein; Enzyme ;
=hexosyltransferase;
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- 13. Amyloid Beta (A4) Precursor Protein (Protease Nexin-II, Alzheimer Disease) Gene
- [This gene is involved in transcriptional activation and mutations in the gene are correlated with Alzheimer disease. ( NCI )] (UMLS (NCI) C1364818) APP;
APP Gene;
=Gene or Genome | - 27. amyotonia congenita
- [congenital atonic pseudoparalysis observed especially in infants and characterized by absence of muscular tone only in muscles innervated by the spinal nerves; also known as Oppenheim's disease or syndrome or congenital atonic pseudoparalysis. ( CSP )] (UMLS (CSP) C0002735) =Congenital Abnormality; Disease or Syndrome ;
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- 14. Amyloid Beta Precursor Protein (Cytoplasmic Tail) Binding Protein 2
- [Encoded by human APPBP2 Gene, ubiquitous 70 kD cytoplasmic Amyloid Beta Precursor Protein-Binding Protein 2 contains terminal globular structures, a coiled coil domain, PKC phosphorylation sites, and four imperfect C-terminal tandem repeats. In the Golgi apparatus, APPBP2 is associated with transport or processing of amyloid precursor protein (APP). Cell surface sorting of the signal-transducing APP depends on a cytoplasmic tyrosine-based basolateral sorting signal (BaSS) sequence to which APPBP2 specifically binds. Amyloid BaSS tyrosine mutation prevents APPBP2 binding and results in nonpolarized transport. Similar to the kinesin light chain, APPBP2 also interacts with microtubules and may have a role in vesicle sorting. APPBP2 is abundantly expressed in breast cancer. (from OMIM, and NCI) ( NCI )] (UMLS (NCI) C1332256) Amyloid Beta Precursor Protein-Binding Protein 2;
APPBP2;
PAT1 Protein;
Protein Interacting with APP Tail 1 =Amino Acid, Peptide, or Protein; Biologically Active Substance | |
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