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UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
%
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
B B B0 B1 B4 B7 B8 BA BB BC BD BE BF BG BH BI BK BL BM BN BO BP BR BS BT BU BV BW BX BY BZ
BE BE+ BEA BEB BEC BED BEE BEF BEG BEH BEI BEK BEL BEM BEN BEP BER BES BET BEU BEV BEX

2-Benzimidazolinebutryric acid, 1-methyl-5-bis(2-chloroethyl)amino-, hydrochloride

[The hydrochloride salt of bendamustine, a novel alkylating agent of the nitrogen mustard family with antitumor activity. Bendamustine, chemically related to the alkylator chlorambucil, has three active moieties: an alkylating group, in common with the nitrogen mustard family; a benzimidazole ring, which may act as a purine analog; and a butyric acid side-chain. This agent undergoes extensive first-pass metabolism by cytochrome p450 enzymes in vivo. One of the hydroxy metabolites, beta-hydroxybendamustine, alkylates and crosslinks macromolecules, thereby resulting in DNA, RNA and protein synthesis inhibition, and subsequently inducing apoptosis. ( NCI )]
UMLS (NCI) C0772139
Bendamustin Hydrochloride
Bendamustine Hydrochloride
 
Organic Chemical
Pharmacologic Substance


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