- 6101. alloantigen
- [ ] (UMLS (CSP) C0002131) =Immunologic Factor
| - 6151. ALP
- [Encoded by human SLPI Gene, 132-aa 14-kDa (precursor) Secretory Leukocyte Protease Inhibitor is an acid-stable proteinase inhibitor with 2 WAP-type domains found in seminal plasma, cervical mucus, and bronchial secretions. With affinity for trypsin, chymotrypsin, leukocyte elastase, and cathepsin G, SLPI contributes to the immune response by protecting epithelial surfaces from attack by endogenous serine proteases. (NCI) ( NCI )] (UMLS (NCI) C0663932) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor
|
- 6102. Allocolchicine
- [An antimitotic agent that binds to tubulin and inhibits tubulin polymerization and arrests proliferation of tumor cells. ( NCI )] (UMLS (NCI) C0051207) =Organic Chemical; Pharmacologic Substance ;
| - 6152. Alper's Syndrome
- (UMLS (NCI) C0205710) =Disease or Syndrome
|
- 6103. Allogeneic bone marrow transplant with purging
- [ ] (UMLS (ICD9CM) C0176708) =Therapeutic or Preventive Procedure
| - 6153. alpha 1 acid glycoprotein
- [family of plasma proteins with oligosaccharide side chains or glycoproteins believed to be associated with inflammation. ( CSP )] (UMLS (CSP) C0029297) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
=blood protein;
glycoprotein;
genetic marker;
|
- 6104. Allogeneic bone marrow transplant without purging
- [ ] (UMLS (ICD9CM) C0176709) =Therapeutic or Preventive Procedure
| - 6154. alpha 1 antitrypsin
- [inflammation-inducible serine protease inhibitor synthesized primarily in liver, then secreted into blood where it accounts for the bulk of blood protease inhibitor activity; is an important regulator of neutrophil elastase. ( CSP )] (UMLS (CSP) C0002191) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Biologically Active Substance
|
- 6105. allogeneic disease
- [ ] (UMLS (CSP) C0002136) =Disease or Syndrome
| - 6155. alpha 1 antitrypsin deficiency
- [autosomal recessive trait leading to destruction of lung tissue by neutrophil elastase and eventual emphysema; second only to cystic fibrosis as most common lethal genetic disorder among Caucasians of northern European ancestry. ( CSP )] (UMLS (CSP) C0221757) =Disease or Syndrome ;
=Connective Tissue Disease;
Congenital Metabolic Disorder |
- 6106. Allogeneic Lymphocyte
- [A population of lymphocytes therapeutically administered to a recipient individual who is genetically distinct from a donor of the same species. (NCI04) ( NCI )] (UMLS (NCI) C0879438) Allogeneic Lymphocytes;
Lymphocytes, Allogeneic;
Therapeutic Allogeneic Lymphocyte =Pharmacologic Substance; Immunologic Factor ;
| - 6156. Alpha 1 Type I Collagen
- [Collagen I (Alpha 1), encoded by the COL1A1 gene, is the major component of type I collagen, the fibrillar collagen found in most connective tissues, and the only component of the collagen found in cartilage. Mutations in this gene are associated with osteogenesis imperfecta, Ehlers-Danlos syndrome, and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. (from LocusLink) ( NCI )] (UMLS (NCI) C0972255) COL1A1;
Collagen Alpha 1(I) Chain;
Collagen I (Alpha 1);
Collagen I, Alpha-1 Polypeptide;
Collagen of Skin, Tendon and Bone, Alpha-1 Chain;
Collagen of Skin, Tendon, and Bone, Alpha-1 Chain;
Collagen, Type I, Alpha 1;
Osteogenesis Imperfecta Type IV;
=Amino Acid, Peptide, or Protein; Biologically Active Substance ;
|
- 6107. Allogeneic Lymphocytes/Cyclosporine
- (UMLS (NCI) C1328158) =Therapeutic or Preventive Procedure; ;
| - 6157. alpha 2 agonist
- [ ] (UMLS (CSP) C0599679) =Pharmacologic Substance
|
- 6108. Allogeneic Lymphocytes/Cyclosporine/Sirolimus
- (UMLS (NCI) C1328159) =Therapeutic or Preventive Procedure; ;
| - 6158. Alpha 2 Interferon
- [A non-glycosylated recombinant human alpha interferon, subtype 2a, produced in the bacterium E. coli. Interferon alpha-2a binds to its specific cell-surface receptor, resulting in the transcription and translation of genes whose protein products have antiviral, antiproliferative, anticancer, and immune modulating effects. (NCI04) ( NCI )] (UMLS (NCI) C0021734) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Immunologic Factor =[IM700] IMMUNE STIMULANTS;
IFNa;
Interferon Type I, Recombinant;
Alpha 2 Interferon =Alpha 2 Interferon;
Interferon Alfa-2a 3000000 UNT/ML;
Interferon Alfa-2a 6000000 UNT/ML;
Interferon Alfa-2a 36000000 UNT/ML;
Interferon Alfa-2a 18000000 UNT;
INTERFERON ALFA-2A,RECOMBINANT 3 MILLION UNT/SYR;
INTERFERON ALFA-2A,RECOMBINANT 9 MILLION UNT/SYR;
INTERFERON ALFA-2A,RECOMBINANT 9MILLION UNT;
|
- 6109. Allogeneic lymphocytes/Interleukin-2
- (UMLS (NCI) C1134601) =Therapeutic or Preventive Procedure
| - 6159. Alpha 2 Type I Collagen
- [Collagen I (Alpha 2), encoded by the COL1A2 gene, is one of the chains for type I collagen, the fibrillar collagen found in most connective tissues. Mutations in this gene are associated with osteogenesis imperfecta, Ehlers-Danlos syndrome, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for alpha-1 type I collagen since alpha-2 is less abundant. Multiple messages for this gene result from multiple polyadenylation signals, a feature shared by most of the other collagen genes. (from LocusLink) ( NCI )] (UMLS (NCI) C0766823) COL1A2;
Collagen Alpha 2(I) Chain;
Collagen I (Alpha 2);
Collagen I, Alpha-2;
Collagen of Skin, Tendon and Bone, Alpha-2 Chain;
Collagen of Skin, Tendon, and Bone, Alpha-2 Chain;
Collagen, Type I, Alpha-2 =Amino Acid, Peptide, or Protein; Pharmacologic Substance ;
|
- 6110. Allogeneic Lymphocytes/Interleukin-2/MOv-Gamma Chimeric Receptor Gene
- (UMLS (NCI) C1327892) =Therapeutic or Preventive Procedure ;
| - 6160. Alpha 3 Type IV Collagen Precursor
- [Collagen IV (Alpha 3),encoded by the human COL4A3 gene, is a subunit of type IV collagen, the major structural component of basement membranes. In Goodpasture syndrome, autoantibodies bind to collagen in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized to the non-collagenous C-terminal domain of this protein. There are 6 alternate transcripts unique to this gene and alternate splicing is restricted to the 6 exons encoding this domain. This protein is widely expressed. Two protein isoforms (1 and 2/Delta26/GPBPD26) are produced by alternative splicing. This gene is also linked to the autosomal recessive Alport syndrome. The mutations contributing to this syndrome are also located within the exons encoding this C-terminal region. This protein phosphorylates the Goodpasture autoantigen in vitro on Ser and Thr residues. Isoform 2 seems less active. (From LocusLink, Swiss-Prot and NCI) ( NCI )] (UMLS (NCI) C1314894) COL4A3;
COL4A3 Protein;
COL4A3BP Protein;
Collagen IV (Alpha 3);
Collagen IV, Alpha-3 Polypeptide;
Collagen of Basement Membrane, Alpha-3 Chain;
Collagen Type IV Alpha 3 Binding Protein;
Collagen, Type IV, Alpha 3 (Goodpasture Antigen);
EC 2.7.1.37;
Goodpasture Antigen;
GPBP Protein;
STARD11 Protein;
STAR-Related Lipid Transfer Protein 11;
START Domain-Containing Protein 11;
TUMSTATIN;
Tumstatin (Human Placenta Collagen Type IV alpha3 Chain NC1 Domain) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
|
- 6111. Allogeneic Lymphocytes/MOv-Gamma Chimeric Receptor Gene
- (UMLS (NCI) C1327891) =Therapeutic or Preventive Procedure ;
| - 6161. Alpha 4 Protein
- [Ubiquitously expressed (highest in heart, skeletal muscle, and pancreas) by human IGBP1 Gene, 339-aa 39-kDa Immunoglobulin Binding Protein 1 is likely involved in IgM/B-Cell Receptor signal transduction. Similar to mouse Igbp1 and yeast TAP42, IGBP1 contains potential N-glycosylation sites, myristylation sites, multiple potential PKC and casein kinase II phosphorylation sites, and an SH3-binding sequence-related stretch. IGBP1 associates with and likely regulates the activity of Ser/Thr phosphatase PP2A-Alpha and PP2A-Beta catalytic subunits. IGBP1 also associates with PP4 and PP6. (NCI) ( NCI )] (UMLS (NCI) C1334162) B Cell Signal Transduction Molecule Alpha 4;
CD79A-Binding Protein 1;
IGBP1;
Immunoglobulin (CD79A) Binding Protein 1;
Immunoglobulin Binding Protein 1 =Amino Acid, Peptide, or Protein; Biologically Active Substance |
- 6112. Allogeneic Prostate Cancer Vaccine, GM- CSF Gene Transduced
- [A whole cell vaccine expressing human granulocyte macrophage-colony stimulating factor (GM-CSF) with potential antineoplastic activity. Tumor cells from prostate cancer patients are harvested and then genetically modified to secrete GM-CSF, an immune stimulatory growth factor that plays a key role in stimulating the body's immune responses against tumor cells. Because the vaccine is derived from allogenic cells, it has demonstrated a favorable side effect profile than other approaches of delivering long-lasting GM-CSF. ( NCI )] (UMLS (NCI) C0796615) Allogenic Prostate GVAX;
GM-CSF Gene Transduced Allogeneic Prostate Cancer Vaccine;
GM-CSF prostate cancer vaccine;
GVAX Allogeneic Prostate Cancer Vaccine;
GVAX Allogenic Prostate Cancer Vaccine;
GVAX Prostate;
GVAX Prostate Cancer Vaccine;
Prostate Cancer Vaccine, GVAX;
Prostrate Cancer Vaccine, GM-CSF Gene Transduced =Pharmacologic Substance; Immunologic Factor ;
| - 6162. alpha actinin
- [cytoskeletal protein present in Z lines of muscle fibrils and at sites of non-muscle cell contact with a substrate. ( CSP )] (UMLS (CSP) C0917705) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
=ABP;
|
- 6113. allogeneic transplantation
- [transplantation between individuals of the same species. ( CSP )] (UMLS (CSP) C0040739) =Therapeutic or Preventive Procedure ;
=transplantation;
| - 6163. alpha adrenergic agent
- [drugs that selectively bind to and activate alpha adrenergic receptors. ( CSP )] (UMLS (CSP) C0178469) =Pharmacologic Substance =adrenergic agent;
|
- 6114. allogenic cell vaccine
- [A vaccine composed of tumor cells isolated from the tumor of one patient, killed and processed, and administered to another patient to stimulate cytotoxic immune responses to a similar tumor cell type. The cells found in this type of whole-cell vaccine express many cell-surface tumor-associated antigens. This vaccine is frequently administered with an adjuvant immunostimulant. (NCI04) ( NCI )] (UMLS (NCI) C1328123) Allogenic Tumor Cell Vaccine =Pharmacologic Substance; Immunologic Factor ;
| - 6164. alpha adrenergic receptor
- [alpha-1 is coupled to phospholipase C, such that stimulation results in production of second messengers DAG and in inositol phosphates; alpha-2 is coupled to adenylate cyclase such that stimulation lowers cyclic AMP. ( CSP )] (UMLS (CSP) C0034784) =Amino Acid, Peptide, or Protein; Receptor ;
=adrenergic receptor;
|
- 6115. allograft
- [ ] (UMLS (CSP) C0522536) =Therapeutic or Preventive Procedure
| - 6165. Alpha Adrenergic Receptor Gene
- [Expressed in effector tissues innervated by postganglionic sympathetic adrenergic fibers, Alpha Adrenergic Receptor Genes encode Alpha Adrenergic Receptors, one of two major classes of adrenergic receptors (alpha and beta) based on their reactions to norepinephrine and epinephrine, on cellular effects of receptor activation, and on relative affinities and reactions to synthetic blocking or stimulating agents. Alpha-adrenergic receptors respond to blocking agents such as phenoxybenzamine and phentolamine. When coupled to adenylate cyclase through Gi protein, Alpha Adrenergic Receptor stimulation results in decreased intracellular cyclic AMP. ( NCI )] (UMLS (NCI) C1332237) =Gene or Genome ;
|
- 6116. Allograft
- (UMLS (HL7) C1546537) =Intellectual Product =Specimen Source Codes;
| - 6166. alpha aminoisobutyrate
- [ ] (UMLS (CSP) C0102457) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
|
- 6117. Allograft
- [A graft transferred from a donor of one species to a recipient of the same species but different genetic makeup. ( NCI )] (UMLS (NCI) C0450127) =Biomedical or Dental Material ;
| - 6167. alpha amylase
- [An enzyme that catalyzes the endohydrolysis of 1,4-alpha-glycosidic linkages in starch, glycogen, and related polysaccharides and oligosaccharides containing 3 or more 1,4-alpha-linked D-glucose units. EC 3.2.1.1. ( MSH )] (UMLS (CSP) C0002245) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Enzyme
|
- 6118. alloimmunity
- [ ] (UMLS (CSP) C0598604) =Organ or Tissue Function
| - 6168. alpha carboxylase
- [also another name for EC 1.2.4.1, PYRUVATE DEHYDROGENASE, do not confuse. ( CSP )] (UMLS (CSP) C0034342) =Amino Acid, Peptide, or Protein; Enzyme ;
=carboxy lyase;
|
- 6119. Alloimmunization
- [Alloimmunization is an immune response to foreign (donor) antigens. ( NCI )] (UMLS (NCI) C0948201) =Disease or Syndrome
| - 6169. alpha catenin
- [A catenin that binds F-ACTIN and links the CYTOSKELETON with BETA CATENIN and GAMMA CATENIN. ( MSH )] (UMLS (CSP) C0108280) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
|
- 6120. Allomyces
- [ ] (UMLS (CSP) C0002140) =Fungus
| - 6170. alpha caveolin
- [ ] (UMLS (CSP) C0287872) =Amino Acid, Peptide, or Protein; Receptor
|
- 6121. Allopathic & Osteopathic Physicians
- [A broad category grouping state licensed providers in allopathic or osteopathic medicine whose scope of practice is determined by education. ( HL7V3.0 )] (UMLS (HL7) C1555723) =Intellectual Product =NUCC Health Care Provider Taxonomy;
=pathologist;
surgeon;
Anesthesiology;
Clinical Pharmacology;
Colon & Rectal Surgery;
Dermatology;
Emergency Medicine;
Family Practice;
General Practice;
Internal Medicine;
Allergy & Immunology;
Legal Medicine;
Medical Genetics;
Neurological Surgery;
Neuromusculoskeletal Medicine & OMM;
Neuromusculoskeletal Medicine, Sports Medicine;
Nuclear Medicine;
Obstetrics & Gynecology;
Ophthalmology;
Oral & Maxillofacial Surgery;
Orthopaedic Surgery;
Otolaryngology;
Pain Medicine;
Pediatrics;
Physical Medicine & Rehabilitation;
Plastic Surgery;
Preventive Medicine;
Psychiatry & Neurology;
Urology;
Radiology;
Hospitalist | - 6171. Alpha Cell
- [A cell in the periphery of the pancreatic islets that secretes glucagon. ( NCI )] (UMLS (NCI) C0030280) =Cell ;
|
- 6122. allosteric site
- [enzyme site which binds molecule other than substrate, thereby regulating enzyme activity. ( CSP )] (UMLS (CSP) C0002146) =Functional Concept
| - 6172. Alpha Cell Neoplasm
- [(GLOO-kuh-guh-NO-ma) A rare pancreatic tumor that produces a hormone called glucagon. Glucagonomas can produce symptoms similar to diabetes. ( NCI )] (UMLS (NCI) C0017689) =Neoplastic Process =Islet Cell Adenoma;
|
- 6123. Allotransplantation of cells of Islets of Langerhans
- [ ] (UMLS (ICD9CM) C0375988) =Therapeutic or Preventive Procedure
| - 6173. Alpha DNA polymerase
- [An enzyme that plays major roles in DNA metabolism. The protein, which exhibits bidirectional nuclease activity is required for both DNA synthesis and repair. DNA polymerase alpha is most active in dividing cells, and is primarily involved with lagging strand synthesis. ( NCI )] (UMLS (NCI) C0012888) =Amino Acid, Peptide, or Protein; Enzyme
|
- 6124. Allovectin-7
- [A substance that is being studied as a gene therapy agent for the treatment of cancer. It increases the ability of the immune system to recognize cancer cells and kill them. ( NCI )] (UMLS (NCI) C0338269) =Nucleic Acid, Nucleoside, or Nucleotide; Lipid; Pharmacologic Substance
| - 6174. Alpha Fetoprotein Increased
- (UMLS (NCI) C0235971) =Finding
|
- 6125. Allovectin-7/Dacarbazine
- (UMLS (NCI) C0796407) =Therapeutic or Preventive Procedure
| - 6175. alpha fucosidase deficiency
- [lysosomal storage disease caused by defective alpha-L-fucosidase and accumulation of fucose containing glycoconjugates; clinical symptoms include psychomotor deterioration, growth retardation, hepatosplenomegaly, cardiomegaly, and seizures. ( CSP )] (UMLS (CSP) C0016788) =Disease or Syndrome ;
=Carbohydrate Metabolism, Inborn Errors;
inborn lysosomal enzyme disorder;
enzyme deficiency;
Lysosomal Storage Diseases, Nervous System |
- 6126. allovectin-7/IL-2
- (UMLS (NCI) C0338270) =Therapeutic or Preventive Procedure
| - 6176. alpha galactosidase
- [hydrolyses terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids. ( CSP )] (UMLS (CSP) C0002268) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Enzyme
|
- 6127. Allow generic substitutions.
- (UMLS (HL7) C1549520) =Idea or Concept =Allow Substitution;
| - 6177. alpha galactosidase deficiency
- [x-linked lysosomal storage disease of glycosphingolipid catabolism, resulting from a deficiency of alpha-galactosidase A and leading to accumulation of ceramide trihexoside in the cardiovascular and renal systems. ( CSP )] (UMLS (CSP) C0002986) =Disease or Syndrome
|
- 6128. Allow Substitution
- (UMLS (HL7) C1550434) =Functional Concept =HL7 Vocabulary Version 2.5;
=Allow generic substitutions.;
Substitutions are NOT authorized. (This is the default - null.);
Allow therapeutic substitutions;
| - 6178. alpha globulin
- [blood plasma or serum protein that is alkaline and has great electrophoretic mobility. ( CSP )] (UMLS (CSP) C0002211) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
|
- 6129. Allow Substitution Codes
- (UMLS (HL7) C1547681) =Intellectual Product =HL7 Vocabulary Version 2.5;
=Contact the Placer Contact Person prior to making any substitutions of this resource;
Substitution of this resource is not allowed;
Notify the Placer Contact Person, through normal institutional procedures, that a substitution of this resource has been made;
Substitution of this resource is allowed | - 6179. alpha glucosidase
- [hydrolyses terminal, non-reducing 1,4-linked alpha-D- glucose residues with release of alpha-D-glucose. ( CSP )] (UMLS (CSP) C0002272) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Enzyme
|
- 6130. Allow therapeutic substitutions
- (UMLS (HL7) C1549522) =Idea or Concept =Allow Substitution;
| - 6180. Alpha Heavy Chain Disease
- [A clonal disorder, also known as immunoproliferative small intestinal disease or Mediterranean lymphoma, characterised by the secretion of a defective alpha heavy chain. It predominantly affects young people in the Mediterranean region. It involves the small intestine, and patients usually present with malabsorption syndrome, abdominal pain, weight loss, and fever. There is extensive villous atrophy of the small intestinal mucosa, which is heavily infiltrated by small lymphocytes and plasma cells. The small intestinal morphologic changes are consistent with a mucosa-associated lymphoid tissue lymphoma (MALT lymphoma). Alpha heavy chain disease frequently progresses to large B-cell lymphoma, and normally has a poor prognosis. ( NCI )] (UMLS (NCI) C0021071) =Neoplastic Process ;
=HCD;
Intestinal Diseases;
lymphoma;
|
- 6131. alloxan
- [pyrimidine ring with carbonyl oxygens at all 4 carbon atoms; an oxidation product of uric acid which, by destroying beta cells in the pancreas, can cause diabetes mellitus; an experimental antineoplastic. ( CSP )] (UMLS (CSP) C0002151) =Biologically Active Substance; Antibiotic ;
| - 6181. alpha helix
- [A right-handed spiral conformation; the a-helix has a pitch of 5.4 A and has 3.6 amino acid residues per turn; every main chain C=O and N-H group is hydrogen-bonded to a peptide bond 4 residues away; the peptide planes are roughly parallel with the helix axis and the dipoles within the helix are aligned, i.e. all C=O groups point in the same direction and all N-H groups point the other way; side chains point outward from helix axis and are generally oriented towards its amino-terminal end. (from expasy.org) ( NCI )] (UMLS (CSP) C0599214) =Spatial Concept
|
- 6132. alloy
- [mixture of two or more metals or of one or more metals with certain metalloids that are mutually soluble in the molten condition; distinguished as binary, ternary, quaternary, etc., depending on the number of metals in the mixture. ( CSP )] (UMLS (CSP) C0002154) =Biomedical or Dental Material; Inorganic Chemical ;
| - 6182. alpha hydroxyketone
- [ ] (UMLS (CSP) C0598751) =Organic Chemical ;
|
- 6133. Allural
- (UMLS (NCI) C1449513) =Organic Chemical; Pharmacologic Substance
| - 6183. Alpha Inhibin
- [The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. (LocusLink) ( NCI )] (UMLS (NCI) C0299209) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
|
- 6134. allyl compound
- [substance that consists of two or more chemical elements in union and containing the univalent organic group, -CH2 or allyl. ( CSP )] (UMLS (CSP) C0002156) =Organic Chemical
| - 6184. Alpha Interferon
- [A class of naturally-isolated or recombinant therapeutic peptides used as antiviral and anti-tumor agents. Alpha interferons are cytokines produced by nucleated cells (predominantly natural killer (NK) leukocytes) upon exposure to live or inactivated virus, double-stranded RNA or bacterial products. These agents bind to specific cell-surface receptors, resulting in the transcription and translation of genes containing an interferon-specific response element. The proteins so produced mediate many complex effects, including antiviral effects (viral protein synthesis); antiproliferative effects (cellular growth inhibition and alteration of cellular differentiation); anticancer effects (interference with oncogene expression); and immune-modulating effects (natural killer cell activation, alteration of cell surface antigen expression, and augmentation of lymphocyte and macrophage cytotoxicity). (NCI04) ( NCI )] (UMLS (NCI) C0751598) alpha-Interferon;
Interferon Alfa;
Leukocyte Interferon;
Lymphoblast Interferon;
Lymphoblastoid Interferon;
Recombinant Interferon Alfa;
=Amino Acid, Peptide, or Protein; Pharmacologic Substance |
- 6135. allylamine
- [Possesses an unusual and selective cytotoxicity for vascular smooth muscle cells in dogs and rats. Useful for experiments dealing with arterial injury, myocardial fibrosis or cardiac decompensation. ( MSH )] (UMLS (CSP) C0002157) =Organic Chemical; Pharmacologic Substance; Hazardous or Poisonous Substance
| - 6185. alpha ketoglutarate
- [intermediate in the Krebs' cycle; also produced from glutamate in amino group transfer reactions and by oxidative deamination. ( CSP )] (UMLS (CSP) C1291208) =Organic Chemical; Pharmacologic Substance =glutarate;
|
- 6136. Almotriptan
- (UMLS (NCI) C0914729) ALMOTRIPTAN PREPARATION;
=Organic Chemical; Pharmacologic Substance ;
=[CN105] ANTIMIGRAINE AGENTS;
Unclassified Ingredients =Almotriptan Malate;
| - 6186. alpha ketoglutarate dehydrogenase
- [component of a multi-enzyme complex which decarboxylates alpha ketoglutarate to form succinyl coA in the Krebs' cycle. ( CSP )] (UMLS (CSP) C0022626) =Amino Acid, Peptide, or Protein; Enzyme =aldehyde/ketone oxidoreductase;
respiratory enzyme |
- 6137. Almotriptan Malate
- [The malate salt of almotriptan, a sulfonamide triptan with vasoconstrictor activity. Almotriptan selectively binds to and activates serotonin 5-HT 1B and 1D receptors in the central nervous system (CNS), thereby causing cerebral blood vessel constriction. This may lead to a relief in pain from vascular headaches. Almotriptan may also relieve vascular headaches by preventing the release of vasoactive neuropeptides from perivascular trigeminal axons in the dura mater during a migraine, by reducing extravasation of plasma proteins, and by decreasing the release of other mediators of inflammation from the trigeminal nerve. ( NCI )] (UMLS (NCI) C0937898) ALMOTRIPTAN MALATE PREPARATION;
=Organic Chemical; Pharmacologic Substance ;
=Almotriptan;
Unclassified Ingredients =ALMOTRIPTAN MALATE 6.25 MG;
ALMOTRIPTAN MALATE 12.5 MG | - 6187. alpha L fucosidase
- [An enzyme that catalyzes the hydrolysis of an alpha L-fucoside to yield an alcohol and L-fucose. Deficiency of this enzyme can cause FUCOSIDOSIS. EC 3.2.1.51. ( MSH )] (UMLS (CSP) C0016787) =Amino Acid, Peptide, or Protein; Enzyme
|
- 6138. ALN
- [Lymph nodes found in the armpit that drain the lymph channels from the breast. ( NCI )] (UMLS (NCI) C0729594) Axillary Lymph Node;
Axillary Lymph Nodes;
Axillary Node =Body Part, Organ, or Organ Component ;
| - 6188. Alpha L Integrin Chain
- [Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. ITGAL encodes the integrin alpha L chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. (from LocusLink) ( NCI )] (UMLS (NCI) C0079091) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor
|
- 6139. Alocril
- (UMLS (NCI) C0876882) =Organic Chemical; Pharmacologic Substance
| - 6189. alpha mannosidase
- [An enzyme that catalyzes the HYDROLYSIS of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. The enzyme plays a role in the processing of newly formed N-glycans and in degradation of mature GLYCOPROTEINS. There are multiple isoforms of alpha-mannosidase, each having its own specific cellular location and pH optimum. Defects in the lysosomal form of the enzyme results in a buildup of mannoside intermediate metabolites and the disease ALPHA-MANNOSIDOSIS. ( MSH )] (UMLS (CSP) C0051350) =Amino Acid, Peptide, or Protein; Enzyme ;
|
- 6140. ALOE
- [A plant genus of the family Aloeaceae, order Liliales (or Asphodelaceae, Asparagales in APG system) which is used medicinally. It contains anthraquinone glycosides such as aloin-emodin or aloe-emodin (EMODIN). ( MSH )] (UMLS (NCI) C0002168) =Plant
| - 6190. alpha methyl p tyrosine
- [An inhibitor of the enzyme TYROSINE 3-MONOOXYGENASE, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with PHEOCHROMOCYTOMA. (Martindale, The Extra Pharmacopoeia, 30th ed) ( MSH )] (UMLS (CSP) C0051427) =Amino Acid, Peptide, or Protein; Pharmacologic Substance ;
=Methyltyrosines;
|
- 6141. Aloe Vera Gel
- [Obtained as a preparation of leaf pulp from the parenchymal tissue of Aloe vera (Liliaceae) and containing carbohydrate polymers, such as glucomannans or pectic acid; various vitamins and essential amino acids; as well as other organic and inorganic compounds, Aloe Vera Gel is used internally or externally for sunburn, skin problems, insect bites, ulcers, arthritis, constipation, and as an immune system enhancer. (NCI04) ( NCI )] (UMLS (NCI) C0974143) ALOE VERA GEL (GM);
ALOE VERA GEL PREPARATION;
ALOE VERA GEL,TOP;
ALOE VERA TOPICAL GEL (GM);
Aloe Vera, topical gel =Clinical Drug =Aloe Vera Gel;
ALOE VERA =Aloe Vera Gel;
CARA-KLENZ,SKIN & WOUND CLEANSER;
I.S.P. LOTION;
Menthol 0.07 MG/MG Topical Gel;
MICRO-KLENZ,ANTIMICROBIAL WOUND CLEANSER;
CARRINGTON WHIRLPOOL SOLN;
CARRINGTON DRESSING GEL SPRAY,TOP;
CARRINGTON GEL,TOP | - 6191. alpha methyldopamine
- [decarboxylation product of the antihypertensive METHYLDOPA. ( CSP )] (UMLS (CSP) C0051413) =Organic Chemical =catecholamine;
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- 6142. ALOMAD
- (UMLS (NCI) C0279217) =Therapeutic or Preventive Procedure
| - 6192. alpha N acetylglucosaminidase
- [ ] (UMLS (CSP) C0051437) =Amino Acid, Peptide, or Protein; Enzyme ;
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- 6143. Alone
- (UMLS (HL7) C0439044) =Finding =Living Arrangement;
| - 6193. Alpha Naphthyl Acetate Esterase Stain
- [A cytochemical staining technique to detect alpha-naphthyl acetate esterase (ANAE) activity. Nonspecific esterase stains with acetate substrate and is mainly used in the determination of lineage in acute myelogenous leukemia. Acute megakaryoblastic leukemia (M7) blasts stain strongly when the acetate substrate is used. ( NCI )] (UMLS (NCI) C1294078) Alpha Naphthyl Acetate Esterase Staining Method;
=Laboratory Procedure |
- 6144. alopecia
- [baldness; absence of hair from skin areas where it is normally present. ( CSP )] (UMLS (CSP) C0002170) =Finding
| - 6194. Alpha Naphthyl Butyrate Esterase Stain
- [A cytochemical staining technique to detect esterase enzyme contained within monocytes and macrophages, which reacts strongly with the substrate alpha-naphthyl butyrate. Monoblastic [FAB M5a (without differentiation) or M5b (with differentiation)] and acute myelomonocytic (M4) leukemias have staining in blasts when the butyrate substrate is employed. Myeloid cells (either malignant or non-malignant) do not stain with nonspecific esterase techniques. ( NCI )] (UMLS (NCI) C1293962) Alpha Naphthyl Butyrate Esterase Staining Method;
Alpha Naphthyl Esterase Stain;
Alpha Naphthyl Esterase Staining Method;
Butyrate-esterase stain =Laboratory Procedure =ObservationMethod;
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- 6145. Alopecia areata
- [A microscopically inflammatory, usually reversible, patchy hair loss occurring in sharply defined areas and usually involving the beard or scalp. (Dorland, 27th ed) ( MSH )] (UMLS (ICD9CM) C0002171) =Disease or Syndrome
| - 6195. Alpha Particle Radiation
- [radioactive decay particles consisting of a helium nucleus (2p2n++) ejected at high speed. ( CSP )] (UMLS (NCI) C0002217) =Natural Phenomenon or Process; Physical Object ;
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- 6146. ALOPECIA NEC
- [ ] (UMLS (ICD9CM) C0029489) =Disease or Syndrome
| - 6196. Alpha Platelet-Derived Growth Factor Receptor
- [Platelet-Derived Growth Factor Receptor, Alpha Polypeptide, encoded by the PDGFRA gene, is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes. (from LocusLink) ( NCI )] (UMLS (NCI) C0290067) =Amino Acid, Peptide, or Protein; Enzyme; Receptor
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- 6147. Alouatta
- [A genus of the subfamily ALOUATTINAE, family ATELIDAE, inhabiting the forests of Central and South America. Howlers travel in groups and define their territories by howling accompanied by vigorously shaking and breaking branches. ( MSH )] (UMLS (CSP) C0002184) =Mammal
| - 6197. alpha secretase
- [ ] (UMLS (CSP) C0379526) =Amino Acid, Peptide, or Protein; Enzyme
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- 6148. Alouattinae
- [A subfamily of ATELIDAE inhabiting the forests of Central and South America. The genus ALOUATTA, or howler monkeys, belongs to this subfamily. ( MSH )] (UMLS (CSP) C0085223) =Mammal
| - 6198. alpha synuclein
- [brain protein of unknown function; mutation is associated with Parkinson's disease. ( CSP )] (UMLS (CSP) C0285890) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
=nerve/myelin protein;
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- 6149. ALOVUDINE
- (UMLS (NCI) C0206795) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
| - 6199. alpha synuclein gene
- [ ] (UMLS (CSP) C0599963) =Gene or Genome ;
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- 6150. ALOX15
- [This gene is involved in hormonal signaling and inflammation. ( NCI )] (UMLS (NCI) C1332082) ALOX15 Gene;
Arachidonate 15-Lipoxygenase Gene;
=Gene or Genome | - 6200. Alpha Thalassemia
- [A disorder characterized by reduced synthesis of the alpha chains of hemoglobin. The severity of this condition can vary from mild anemia to death, depending on the number of genes deleted. ( MSH )] (UMLS (NCI) C0002312) =Disease or Syndrome
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