- 1. VINBLASTINE
- [promotes paracrystalline aggregates of tubulin and thus inhibits microtubule formation; used as a cytologic probe for microtubule function, and clinically as an antineoplastic. ( CSP )] (UMLS (NCI) C0042670) =Organic Chemical; Pharmacologic Substance; Biologically Active Substance =[AN000] ANTINEOPLASTICS;
vinca alkaloid =VINBLASTINE SULFATE;
3',4'-Didehydro-4'-deoxy-C'-norvincaleukoblastine;
VINBLASTINE SULFATE | - 8. vinegar fly
- [ ] (UMLS (CSP) C0598324) =Invertebrate
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- 2. vinca alkaloid
- [nitrogenous basic compounds produced by the Madagascar periwinkle; they are cytotoxic and cell cycle specific for the M phase of cell division. ( CSP )] (UMLS (CSP) C0042672) =Organic Chemical; Pharmacologic Substance ;
=alkaloid;
carbazole =VINBLASTINE;
22-Oxovincaleukoblastine;
VINBLASTINE;
22-Oxovincaleukoblastine;
| - 9. Vinorelbine/Zosuquidar Trihydrochloride
- (UMLS (NCI) C0879361) =Therapeutic or Preventive Procedure ;
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- 3. Vincaleukoblastine, O4-Deacetyl-3-de(methoxycarbonyl)-3-(((1-(diethoxyphosphinyl)-2-methylpropyl)amin)carbonyl)-,(3(S))-,Sulfate(Salt)
- [An aminophosphonate derivative of a vinca alkaloid with potential antineoplastic activity. Vinfosiltine exerts its antineoplastic action just like its parent compound, vinblastine, by immobilizing tubulin molecules, thereby interrupting microtubule assembly/disassembly dynamics. As a result, vinfosiltine prevents mitotic spindle formation and leads to cell cycle arrest in metaphase. ( NCI )] (UMLS (NCI) C0281309) =Organic Chemical; Pharmacologic Substance
| - 10. Vinyl Carbamate
- [A synthetic organic compound produced in industry, Vinyl Carbamate is used in biomedical research to induce experimental (especially skin and lung) tumors in animals. Metabolism of Vinyl Carbamate leads to formation of electrophilic reactants that covalently bind to macromolecules (DNA-, RNA-, and protein-adducts) and initiate carcinogenesis. (NCI04) ( NCI )] (UMLS (NCI) C0078262) =Organic Chemical
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- 4. vincamine
- [A major alkaloid of Vinca minor L., Apocynaceae. It has been used therapeutically as a vasodilator and antihypertensive agent, particularly in cerebrovascular disorders. ( MSH )] (UMLS (CSP) C0042674) =Organic Chemical; Pharmacologic Substance ;
| - 11. vinyl ether
- [1,1'oxybisethene; divinyl ether; C4H6O. ( CSP )] (UMLS (CSP) C0078264) =Organic Chemical; Pharmacologic Substance ;
=ETHER;
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- 5. Vincasar
- (UMLS (NCI) C0733847) =Organic Chemical; Pharmacologic Substance ;
| - 12. vinylbenzene polymer
- [ ] (UMLS (CSP) C0599173) =Organic Chemical; Biomedical or Dental Material
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- 6. Vincristine Sulfate Liposome
- [A sphingomyelin/cholesterol liposomal formulation of vincristine sulfate with potential antineoplastic activity. Vincristine, a vinca alkaloid isolated from the plant Vinca rosea, irreversibly binds to and stabilizes tubulin, thereby interrupting microtubule assembly/disassembly dynamics, thereby preventing the formation of the mitotic spindle and leading to cell cycle arrest in metaphase. Liposomal encapsulation prolongs bioavailability of vincristine, increases its delivery to tumor tissues and reduces its toxicity profile. Compared to standard liposomal delivery, sphingosomal drug delivery further increases circulation time of serum drug and enhances drug accumulation at tumor sites, thereby leading to a further increase in efficacy. ( NCI )] (UMLS (NCI) C0935690) =Organic Chemical; Pharmacologic Substance ;
| - 13. vinyledene chloride
- [1,1-dichloroethene; 1,1-dichloroethylene; C2H2Cl2. ( CSP )] (UMLS (CSP) C0078277) =Organic Chemical; Hazardous or Poisonous Substance ;
=haloalkene;
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- 7. VINDOLINE
- [An indole alkaloid that exhibits antimitotic activity by inhibiting microtubule assembly. (NCI) ( NCI )] (UMLS (NCI) C0078250) =Organic Chemical; Pharmacologic Substance ;
| - 14. Vinzolidine
- [An orally active semisynthetic vinca alkaloid with potential antineoplastic activity. Like other vinca alkaloid compounds, vinzolidine binds to and stabilizes tubulin molecules, thereby interfering with microtubule assembly/disassembly dynamics. As a result, vinzolidine prevents mitotic spindle formation and leads to cell cycle arrest in metaphase. ( NCI )] (UMLS (NCI) C0078282) =Organic Chemical; Pharmacologic Substance ;
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