- 1. TNF
- [This gene is involved in apoptosis, cell growth and cell proliferation. It also plays a role in immune and inflammatory responses. ( NCI )] (UMLS (NCI) C0812246) TNF Gene;
Tumor Necrosis Factor (TNF Superfamily, Member 2) Gene =Gene or Genome | - 14. TNFRSF10A
- [This gene is involved in cell death signal transduction and apoptosis mediation. ( NCI )] (UMLS (NCI) C1336643) TNFRSF10A Gene;
Tumor Necrosis Factor Receptor Superfamily, Member 10A Gene =Gene or Genome ;
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- 2. TNF (unspecified)
- [Family of cell surface proteins structurally related to tumor necrosis factor. They are involved in lymphocyte homeostasis by their ability to induce apoptosis. ( NCI )] (UMLS (CSP) C0041368) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
| - 15. TNFRSF10B
- [This gene is involved in apoptotic signal transduction via receptor interactions. ( NCI )] (UMLS (NCI) C1336644) TNFRSF10B Gene;
Tumor Necrosis Factor Receptor Superfamily, Member 10B Gene =Gene or Genome ;
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- 3. TNF Alpha ICE Proteinases
- [Tightly regulated and activated by proteolysis, TNF Alpha ICE Proteinases (ICE/CED3/Caspase Family, MEROPS C14 Peptidase Family) are Cysteine-dependent ASPartyl-specific proteASE (Caspases) effectors (active alpha2/beta2-tetrameric enzymes) of the extrinsic apoptosis cascade, induced by TNF cytokine stimulation of cell surface TNF receptors. By promoting a death-inducing signaling complex (DISC) between recruited FADD and caspase-8, activated receptors transmit signal to the cytoplasm and caspase-8 activation initiates an apoptosis cascade involving caspases 3, 4, 6, 7, 9 and 10 that destroys the cell by disintegrating its contents, including its DNA. The Caspase Family includes Caspases 1-14, ced-3 and Drosophila Ice. ( NCI )] (UMLS (NCI) C1336651) =Amino Acid, Peptide, or Protein; Enzyme
| - 16. TNFRSF11B
- [This gene is involved in the negative regulation of bone resorption. ( NCI )] (UMLS (NCI) C1336645) TNFRSF11B Gene;
Tumor Necrosis Factor Receptor Superfamily, Member 11B (Osteoprotegerin) Gene =Gene or Genome ;
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- 4. TNF Assay
- [An immunoassay to detect Tumor Necrosis Factor (TNF), which is a potent lymphoid factor, and exerts cytotoxic effects on a wide range of tumor cells and other target cells. Utilizes monoclonal antibody to TNF immobilized on microtitre plate. ( NCI )] (UMLS (NCI) C0201595) =Laboratory Procedure
| - 17. TNFRSF1A
- [This gene modulates a variety of cellular functions such as apoptosis and inflammatory responses. ( NCI )] (UMLS (NCI) C1363984) TNFRSF1A Gene;
Tumor Necrosis Factor Receptor Superfamily, Member 1A Gene =Gene or Genome ◊ [This protein is a member of the TNF-receptor superfamily. It is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. (LocusLink) ( NCI )] (UMLS (NCI) C1453722) Tumor Necrosis Factor Binding Protein 1; Tumor Necrosis Factor Receptor Superfamily, Member 1A; Tumor Necrosis Factor Receptor Type 1; Tumor Necrosis Factor-Alpha Receptor Amino Acid, Peptide, or Protein; Receptor |
- 5. TNF Family Gene
- [Tumor Necrosis Factor Family Genes encode Tumor Necrosis Factor Family Protein, structurally related cell surface proteins involved in lymphocyte homeostasis by induction of apoptosis. ( NCI )] (UMLS (NCI) C1336836) Tumor Necrosis Factor Family Gene =Gene or Genome ;
| - 18. TNFRSF1A-Associated via Death Domain Gene
- [This gene plays a role in signal transduction and regulation of apoptosis. ( NCI )] (UMLS (NCI) C1336664) TRADD;
TRADD Gene =Gene or Genome ;
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- 6. TNF Ligand-Related Molecule 1
- [Vascular Endothelial Growth Inhibitor is a TNF-related type II transmembrane protein, with an extracellular C-terminus, a single transmembrane domain, and a short cytoplasmic tail. VEGI is expressed as multiple mRNAs in most tissues, arterial endothelial cells, and monocytes, but not in B- or T-cells. Soluble VEGI markedly reduces vascularization and inhibits the growth of aortic endothelial cells and colon carcinomas. VEGI appears to be an angiogenesis inhibitor that directly inhibits endothelial cell proliferation. VEGI appears to cause endothelial cell apoptosis by activation of the SAPK/JNK stress protein kinases, p38 MAPK, and caspase-3. (from OMIM 604052 and NCI) ( NCI )] (UMLS (NCI) C0762871) TNFSF15;
Tumor Necrosis Factor Ligand Superfamily Member 15;
Vascular Endothelial Growth Inhibitor;
VEGI;
=Amino Acid, Peptide, or Protein; Biologically Active Substance | - 19. TNFRSF1B
- [This gene is involved in the regulation of apoptotic receptor-mediated signal transduction and inflammatory responses. ( NCI )] (UMLS (NCI) C1363982) TNFRSF1B Gene;
Tumor Necrosis Factor Receptor Superfamily, Member 1B Gene =Gene or Genome |
- 7. TNF Receptor Family Gene
- [Human TNF Receptor Family Genes encode transmembrane receptor proteins regulated by TNF Family ligands. TNF receptors typically contain intracellular death domains involved in the formation of a signal transducing death-inducing complex that includes FADD and caspases that trigger an apoptotic caspase cascade. Some TNF receptors can activate NF-Kappa-B, MAPK3/ERK1, MAPK8/JNK, BIRC1, BIRC2, BAG4/SODD, TRADD, or TRAF2 and transduce inflammation or anti-apoptotic proliferating signals. Some TNF Family Receptors act as competitive decoy receptors in bone resorption or suppress FasL- and LIGHT-mediated cell death. (NCI) ( NCI )] (UMLS (NCI) C1336652) =Gene or Genome ;
| - 20. TNFRSF6B
- [This gene plays a regulatory role in receptor-mediated apoptosis. ( NCI )] (UMLS (NCI) C1367454) TNFRSF6B Gene;
Tumor Necrosis Factor Receptor Superfamily, Member 6B, Decoy Gene =Gene or Genome |
- 8. TNF Receptor-Associated Factor 2
- [TRAF2 is a homo- or (with TRAF1) heterodimer adaptor protein for TNFR1, TNFR2, and CD40 that mediates activation of NFKB. TRAF2 contains a TRAF motif known to bind kinases involved in TRAF-mediated signaling, a Zn RING finger, and cysteine/histidine-rich motifs. E2F1 can down regulate TRAF2 and inhibit anti-apoptotic NFKB signals. (from OMIM 601895 and NCI) ( NCI )] (UMLS (NCI) C0258441) =Amino Acid, Peptide, or Protein; Biologically Active Substance
| - 21. TNFRSF8
- [This gene is involved in pro-apoptotic regulation via the NF-kappaB signal transduction pathway. ( NCI )] (UMLS (NCI) C1456796) TNFRSF8 Gene;
Tumor Necrosis Factor Receptor Superfamily, Member 8 Gene =Gene or Genome ;
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- 9. TNF Receptor-Associated Factor 2 Gene
- [This gene is involved in signal transduction and inhibition of apoptosis. ( NCI )] (UMLS (NCI) C1366777) TRAF2;
TRAF2 Gene =Gene or Genome | - 22. TNFSF10
- [This gene is involved in apoptosis and inflammatory responses. ( NCI )] (UMLS (NCI) C1336646) TNFSF10 Gene;
Tumor Necrosis Factor (Ligand) Superfamily, Member 10 Gene =Gene or Genome ;
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- 10. TNF Receptor-Associated Factor 4 Gene
- [This gene is involved in signal transduction and development. It plays a putative role in the positive regulation of apoptosis in response to cellular stress. ( NCI )] (UMLS (NCI) C1336665) TRAF4;
TRAF4 Gene =Gene or Genome ;
| - 23. TNFSF11
- [This gene is involved in apoptosis and osteoclast differentiation. ( NCI )] (UMLS (NCI) C1367028) TNFSF11 Gene;
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 Gene =Gene or Genome |
- 11. TNF Receptor-Associated Factor 6 Gene
- [This gene plays a role in signal transduction and regulation of apoptosis. It is also involved in the immune response and bone homeostasis. ( NCI )] (UMLS (NCI) C1336666) TRAF6;
TRAF6 Gene =Gene or Genome ;
| - 24. TNFSF15
- [This gene plays an inhibitory role in angiogenesis regulation. ( NCI )] (UMLS (NCI) C1336647) TNFSF15 Gene;
Tumor Necrosis Factor Ligand Superfamily Member 15 Gene =Gene or Genome ;
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- 12. TNF Receptor-Associated Protein with a Death Domain
- [TRADD is an adaptor protein involved in the recruitment of FADD or TRAF signaling proteins into TNF-stimulated cell death or NFKB induction. TRADD contains a death domain, similar to that of TNFR1, capable of mediating TRADD oligomerization, interaction with the TNFR1 death domain, stimulation of apoptosis, and NFKB activation. TNF-induced apoptosis involves TRADD-mediated ICE cysteine protease activation. NFKB activation by TRADD involves a different pathway. (from J Leukoc Biol 1998. 63:678, OMIM 603500, and NCI) ( NCI )] (UMLS (NCI) C0289012) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 25. TNFSF4
- [This gene is involved in T-cell regulation. ( NCI )] (UMLS (NCI) C1336648) TNFSF4 Gene;
Tumor Necrosis Factor (Ligand) Superfamily, Member 4 (Tax-Transcriptionally Activated Glycoprotein 1, 34kDa) Gene =Gene or Genome ;
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- 13. TNFR:Fc
- (UMLS (NCI) C0281500) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Immunologic Factor
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