TNFRSF1A

1. [This gene modulates a variety of cellular functions such as apoptosis and inflammatory responses. ( NCI )]
   UMLS (NCI) C1363984
   
   TNFRSF1A Gene
   Tumor Necrosis Factor Receptor Superfamily, Member 1A Gene
    

   Gene or Genome

2. [This protein is a member of the TNF-receptor superfamily. It is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. (LocusLink) ( NCI )]
   UMLS (NCI) C1453722
   
   Tumor Necrosis Factor Binding Protein 1
   Tumor Necrosis Factor Receptor Superfamily, Member 1A
   Tumor Necrosis Factor Receptor Type 1
   Tumor Necrosis Factor-Alpha Receptor
    

   Amino Acid, Peptide, or Protein

   Receptor