[RGS family proteins activate GTPase and regulate G protein signaling by stimulating the inactivation of heterotrimeric G proteins. RGS family proteins are responsible for the rapid turnoff of G protein-coupled receptor signaling pathways. There are indications that a subset of RGS proteins regulate specific G protein-coupled receptor pathways. ( NCI )] (UMLS (NCI) C0633372) =Amino Acid, Peptide, or Protein; Biologically Active Substance