- 1. (-)-(R)-1-(4,4-Bis(3-methyl-2-thienyl)-3-butenyl)nipecotic Acid, Hydrochloride
- [The hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. Tiagabine hydrochloride inhibits the gamma-aminobutyric acid (GABA) transporter type 1 (GAT1), which is predominantly localized in presynaptic terminals of neurons thereby preventing the reuptake of GABA by the presynaptic endings. Consequently, this increases the level of available GABA within the synaptic cleft, thereby resulting in prolongation of its inhibitory actions. Tiagabine is effective against maximum electroshock seizures and both limbic and generalized tonic-clonic seizures. ( NCI )] (UMLS (NCI) C0772200) 3-Piperidinecarboxylic Acid, 1-(4,4-bis(3-methyl-2-thienyl)-3-buten-yl)-, Hydrochloride,(R)-;
Tiagabine Hydrochloride;
TIAGABINE HYDROCHLORIDE PREPARATION =Organic Chemical; Pharmacologic Substance =TIAGABINE;
=TIAGABINE HYDROCHLORIDE 12 MG;
TIAGABINE HYDROCHLORIDE 16 MG;
TIAGABINE HYDROCHLORIDE 4 MG;
TIAGABINE HYDROCHLORIDE 2 MG | - 3. Rb81 isotope
- [ ] (UMLS (CSP) C0303553) =Element, Ion, or Isotope
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- 2. 9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)phosphinyl)methoxy)propyl)adenine, Fumarate
- [A pro-drug, a fumaric acid salt of tenofovir and an acyclic nucleoside phosphonate diester analog with antiviral property. In vivo tenofovir disoproxil fumarate is converted into tenofovir by diester hydrolysis in the intestinal lumen and plasma, followed by internalization into cells by endocytosis and subsequent phosphorylation into tenofovir diphosphate. Tenofovir diphosphate competes with the natural substrate dATP for incorporation into viral DNA by reverse transcriptase of human immunodeficiency virus (HIV). The substituted DNA-tenofovir diphosphate molecule prevents further DNA elongation, and consequently impairs viral replication and propagation. This agent prevents HIV from reproducing in uninfected cells only. Tenofovir also exhibits activity against the hepatitis B virus (HBV). ( NCI )] (UMLS (NCI) C1099776) TDF;
Tenofovir DF;
Tenofovir Disoproxil Fumarate;
TENOFOVIR DISOPROXIL FUMARATE PREPARATION;
=Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance =TENOFOVIR;
Unclassified Ingredients =TENOFOVIR DISOPROXIL FUMARATE 300 MG | - 4. Rb86 isotope
- [ ] (UMLS (CSP) C0303558) =Indicator, Reagent, or Diagnostic Aid; Element, Ion, or Isotope ;
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