9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)phosphinyl)methoxy)propyl)adenine, Fumarate
[A pro-drug, a fumaric acid salt of tenofovir and an acyclic nucleoside phosphonate diester analog with antiviral property. In vivo tenofovir disoproxil fumarate is converted into tenofovir by diester hydrolysis in the intestinal lumen and plasma, followed by internalization into cells by endocytosis and subsequent phosphorylation into tenofovir diphosphate. Tenofovir diphosphate competes with the natural substrate dATP for incorporation into viral DNA by reverse transcriptase of human immunodeficiency virus (HIV). The substituted DNA-tenofovir diphosphate molecule prevents further DNA elongation, and consequently impairs viral replication and propagation. This agent prevents HIV from reproducing in uninfected cells only. Tenofovir also exhibits activity against the hepatitis B virus (HBV). ( NCI )]
UMLS (NCI) C1099776TDF
Tenofovir DF
Tenofovir Disoproxil Fumarate
TENOFOVIR DISOPROXIL FUMARATE PREPARATION
Tenofovir DF
Tenofovir Disoproxil Fumarate
TENOFOVIR DISOPROXIL FUMARATE PREPARATION
- Nucleic Acid, Nucleoside, or Nucleotide
- Pharmacologic Substance
Relation/PAR: TENOFOVIR
Unclassified Ingredients
Unclassified Ingredients
Relation/CHD: TENOFOVIR DISOPROXIL FUMARATE 300 MG
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