- 1. PKC
- [nonEC. ( CSP )] (UMLS (NCI) C0033634) =Amino Acid, Peptide, or Protein; Enzyme ;
=alcohol phosphotransferase;
| - 3. PKCA
- [Encoded by human PRKCA Gene (PKC Family), 672-aa 77-kDa Protein Kinase C-alpha is a calcium-activated (likely by the C2 domain), DAG-activated, phospholipid-dependent serine/threonine kinase containing 2 zinc-dependent phorbol-ester/DAG binding domains and a C2 domain that phosphorylates a range of cellular proteins. DAG markedly increases PKC sensitivity to calcium and phospholipids. PKC activation appears to be central in the induction of cellular responses to many ligand-receptor systems and to external stimuli. After GPCR stimulation, and triggered by PKC-dependent serine phosphorylation, RKIP dissociates from RAF1 to associate with and block GRK2 activity. By activating PKC, the receptor signal may be enhanced by removing a RAF1 inhibitor and blocking receptor internalization. A receptor for phorbol ester tumor promoters, PKC may interact with PRKCABP. (NCI) ( NCI )] (UMLS (NCI) C0256371) =Amino Acid, Peptide, or Protein; Enzyme ;
|
home 
Armenian-English 
top