[Encoded by human PSIP1 Gene, Transcriptional Coactivator p52 is an alternatively spliced product that shares a 325-aa region with Transcriptional Coactivator p75, but shows distinct coactivator properties. p52 interacts strongly with the VP16 activation domain and with components of the general transcriptional machinery. A potent broad-specificity coactivator, p52 interacts with transcriptional activators and general transcription factors, as well as with ASF/SF2 to modulate pre-mRNA splicing. Most p52 appears to be colocalized with ASF/SF2 in the nucleoplasm. p52 may coordinate pre-mRNA splicing and transcriptional activation of class II genes. (NCI) ( NCI )] (UMLS (NCI) C0761476) PAIP; PC4 and SFRS1 Interacting Protein 1; PC4 and SFRS1 Interacting Protein 2; PSIP1; PSIP2; Transcriptional Coactivator p52; =Amino Acid, Peptide, or Protein; Biologically Active Substance ;