- 1. Lomefloxacin
- [A synthetic broad-spectrum fluoroquinolone with antibacterial activity. Lomefloxacin inhibits DNA gyrase, a type II topoisomerase involved in the induction or relaxation of supercoiling during DNA replication. This inhibition leads to a decrease in DNA synthesis during bacterial replication, resulting in cell growth inhibition and eventually cell lysis. ( NCI )] (UMLS (NCI) C0065162) =Organic Chemical; Pharmacologic Substance ;
=Quinolones; [AM900] ANTI-INFECTIVES, OTHER =(+-)-1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid, monohydrochloride; | - 5. Lomustine/Procarbazine
- (UMLS (NCI) C0796683) =Therapeutic or Preventive Procedure
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