UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM - Terms starting with ‘L’

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UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM

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I I- I0 I1 I2 I3 I4 I5 I6 I7 I8 I9 IA IB IC ID IE IF IG IH II IK IL IM IN IO IP IQ IR IS IT IU IV IX

IGA IGB IGD IGE IGF IGG IGH IGI IGK IGL IGM IGN IGU

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1. IGL: [This region represents the germline organization of the lambda light chain locus. The locus includes V (variable), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. (from LocusLink) ( NCI )] (UMLS (NCI) C1334165) Immunoglobulin Lambda Gene;
Immunoglobulin Lambda Locus;
Lambda Light Chain Gene =Gene or Genome ;

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