- 1. IGF
- [insulin-like polypeptides made by the liver and some fibroblasts and released into the blood when stimulated by somatotropin; they cause sulfate incorporation into collagen, RNA, and DNA synthesis, which are prerequisites to cell division and growth of the organism. ( CSP )] (UMLS (NCI) C0037657) =Amino Acid, Peptide, or Protein; Neuroreactive Substance or Biogenic Amine; Hormone =Growth Agents;
| - 12. IGF1R
- [This gene is involved in the regulation of apoptosis and cell proliferation and plays a role in cellular transformation and malignancy. ( NCI )] (UMLS (NCI) C1334088) IGF1R Gene;
Insulin-Like Growth Factor 1 Receptor Gene =Gene or Genome |
- 2. IGF binding protein
- [A family of soluble proteins that bind insulin-like growth factors and modulate their biological actions at the cellular level. Serum IGFBP levels have been found to be negatively correlated to the risk of cancer. ( NCI )] (UMLS (CSP) C0074825) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 13. IGF2
- [This gene plays a role in cell growth and proliferation. It is also involved in the regulation of prenatal skeletal and muscular development. ( NCI )] (UMLS (NCI) C1334091) IGF2 Gene;
Insulin-Like Growth Factor 2 (Somatomedin A) Gene =Gene or Genome |
- 3. IGF Binding Protein 3
- [IGFBP3 belongs to the IGFBP family. IGFBP3 functions as the major carrying protein for IGF1 and IGF2 in the circulation, modulates IGF activity, and inhibits cell growth. IGFBP3 binds IGF-II more than IGF-I. Endothelial IGFBP3 forms a ternary complex with IGF-I or IGF-II and an 85 kD glycoprotein (ALS). IGFBP3 levels increase in the presence of IGF-I, insulin and other growth-stimulating factors such as growth hormone, epidermal growth factor, and phorbol esters. IGFBP3 may control angiogenesis and cell responses in the corpus luteum by autocrine/paracrine mechanisms. IGFBP3 also possesses growth-inhibitory and -potentiating effects that are independent of IGF and are mediated through specific receptors. As a specific IGFBP3-binding protein, transferrin blocks IGFBP3-induced cell proliferation and IGFBP3-induced apoptosis. (from OMIM 146732, SWISS-PROT P17936, and NCI) ( NCI )] (UMLS (NCI) C0123707) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Biologically Active Substance
| - 14. IGF2R
- [This gene is involved in intracellular trafficking and receptor signaling. ( NCI )] (UMLS (NCI) C1334090) IGF2R Gene;
Insulin-Like Growth Factor 2 Receptor Gene =Gene or Genome |
- 4. IGF Binding Protein 4
- [IGFBP4 belongs to the IGFBP family. IGFs, IGFRs, and IGFBPs regulate cell proliferation and apoptosis and the primary effect of IGFBPs appears to be modulation of IGF activity and control of IGF-mediated cell growth and metabolism. IGF-I and IGF-II circulate in plasma tightly bound to IGFBPs. Secreted IGFBPs prolong the half-life of IGFs (somatomedins) and either inhibit or stimulate the growth promoting effects of IGFs. They alter the interaction of IGFs with cell surface receptors. IGFBP4 contains a thyroglobulin type-I domain and binds IGF-II more than IGF-I. IGFBP4 inhibits IGF-induced bone cell proliferation. (from OMIM 146733, SWISS-PROT P22692, and NCI) ( NCI )] (UMLS (NCI) C0123258) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 15. IGFBP1
- [This gene plays a role in insulin-like growth factor modulation and degradation. ( NCI )] (UMLS (NCI) C1334092) IGFBP1 Gene;
Insulin-Like Growth Factor Binding Protein 1 Gene =Gene or Genome |
- 5. IGF Binding Protein 5
- [IGFBP5 contains a thyroglobulin type-I domain and belongs to the IGFBP family. IGFBPs display strong sequence homologies. IGFBPs contain three distinct domains. N-terminal domain 1 and C-terminal domain 3 contain invariant cysteine residues and are thought to be the IGF binding domains. Domain 2 generally lacks sequence identity among the IGFBPs. Domain 3 is homologous to the thyroglobulin type I repeat. IGF-I and IGF-II circulate in plasma tightly bound to IGFBPs. IGFs, IGFRs, and IGFBPs regulate cell proliferation and apoptosis; the primary effect of IGFBPs appears to be modulation of IGF activity and control of IGF-mediated cell growth and metabolism. Secreted IGF-binding proteins prolong the half-life of IGFs (somatomedins) and either inhibit or stimulate the growth promoting effects of IGFs; they alter the interaction of IGFs with cell surface receptors. (from OMIM 146734, SWISS-PROT P22692, and NCI) ( NCI )] (UMLS (NCI) C0123259) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 16. IGFBP2
- [This gene plays a role in insulin-like growth factor modulation and intercellular communication. ( NCI )] (UMLS (NCI) C1334093) IGFBP2 Gene;
Insulin-Like Growth Factor Binding Protein 2, 36kDa Gene =Gene or Genome |
- 6. IGF I
- [Elevated serum levels of insulin-like growth factor-1 (IGF-1) may identify premenopausal women who are likely to develop breast cancer before age 50. (from Int J Cancer 2000;88:828-832 via Medscape) ( NCI )] (UMLS (CSP) C0021665) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 17. IGFBP3
- [This gene plays an inhibitory role in the regulation of extravascular tissue growth. ( NCI )] (UMLS (NCI) C1334094) IGFBP3 Gene;
Insulin-Like Growth Factor Binding Protein 3 Gene =Gene or Genome |
- 7. IGF II
- [Insulin-like growth factors I and II, also known as somatomedin C and somatomedin A, respectively, are single chain polypeptides which share an amino acid sequence homology of about 47% with insulin and about 31% with relaxin and with them comprise the insulin family of polypeptide growth factors. Their functions include mediation of growth hormone action, stimulation of growth of cultured cells, stimulation of the action of insulin, and involvement in development and growth. They appear to be autocrine regulators of cell proliferation. ( NCI )] (UMLS (CSP) C0021666) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 18. IGFBP4
- [This gene plays a role in insulin-like growth factor modulation and cellular growth inhibition. ( NCI )] (UMLS (NCI) C1334095) IGFBP4 Gene;
Insulin-Like Growth Factor Binding Protein 4 Gene =Gene or Genome |
- 8. IGF Receptor
- [The protein on surface of target cells specific for binding IGF. There are two types of IGF receptor, one of which closely resembles the insulin receptor. ( NCI )] (UMLS (NCI) C0140079) =Amino Acid, Peptide, or Protein; Receptor
| - 19. IGFBP5
- [This gene plays a role in the intracellular transport of insulin-like growth factor moieties. ( NCI )] (UMLS (NCI) C1334096) IGFBP5 Gene;
Insulin-Like Growth Factor Binding Protein 5 Gene =Gene or Genome |
- 9. IGF-II mRNA-Binding Protein 3
- [Encoded by human KOC1 Gene, IGF-II mRNA-Binding Protein 3 contains a KH domain and binds to the 5-prime UTR of the IGF-II leader 3-prime mRNA. It may repress translation of IGF-II during late development. (from LocusLink and NCI) ( NCI )] (UMLS (NCI) C0539906) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 20. IGFBP6
- [This gene plays an inhibitory role in the regulation of cellular growth. ( NCI )] (UMLS (NCI) C1367148) IGFBP6 Gene;
Insulin-Like Growth Factor Binding Protein 6 Gene =Gene or Genome ◊ [IGFBP6 contains a thyroglobulin type-I domain, belongs to the IGFBP family, and may function as an autocrine growth inhibitor. IGFBPs display strong sequence homologies. IGFBPs contain three distinct domains. N-terminal domain 1 and C-terminal domain 3 contain invariant cysteine residues and are the IGF binding domains. Domain 2 generally lacks sequence identity among the IGFBPs. Domain 3 is homologous to the thyroglobulin type I repeat. IGF-I and IGF-II circulate in plasma tightly bound to IGFBPs. IGFs, IGFRs, and IGFBPs regulate cell proliferation and apoptosis and the primary effect of IGFBPs appears to be modulation of IGF activity and control of IGF-mediated cell growth and metabolism. Secreted IGF-binding proteins prolong the half-life of IGFs (somatomedins) and either inhibit or stimulate the growth promoting effects of IGFs by altering the interaction of IGFs with cell surface receptors. (from OMIM 146735, SWISS-PROT P24592 and NCI) ( NCI )] (UMLS (NCI) C1442822) Amino Acid, Peptide, or Protein; Biologically Active Substance |
- 10. IGF1
- [This gene is involved in cellular communication, growth and proliferation. It also plays a role in the regulation of muscular and skeletal development. ( NCI )] (UMLS (NCI) C1334089) IGF1 Gene;
Insulin-Like Growth Factor 1 (Somatomedin C) Gene =Gene or Genome | - 21. IGFBP9
- [A product of the NOV gene. It is a member of the CCN family of proteins, expressed after induction by growth factors. CCN proteins share several motifs: an IGFBP motif, an oligomeric complex-forming domain, a binding domain for soluble and matrix molecules, and a dimerization CT domain. All CCN members are thought to control cell proliferation. (from OMIM 164958 and NCI) ( NCI )] (UMLS (NCI) C1334190) Insulin-Like Growth Factor-Binding Protein-9;
NOV =Amino Acid, Peptide, or Protein; Biologically Active Substance |
- 11. IGF1R
- [Human insulin-like growth factor-1 receptor protein (1367 aa, 155 kDa precursor) is encoded by the human insulin-like growth factor-1 (IGFR1) gene. This membrane-bound protein, a disulfide-linked alpha2/beta2 tetramer, binds both insulin growth factors I and II. Ligand binding activates protein kinase activity, controls cell cycle progression and enhances cell survival. ( NCI )] (UMLS (NCI) C0140080) =Amino Acid, Peptide, or Protein; Enzyme; Receptor
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