- 1. EC 1.1.1.204
- [A homodimer, belongs to the family of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Xanthine oxidase (EC 1.1.3.22), a unimolecular, multicomponent electron transport system (with cofactors), catalyzes the oxidation of xanthine to uric acid. Xanthine dehydrogenase is the mian form exists in liver in vivo. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism. (NCI) ( NCI )] (UMLS (NCI) C0043316) =Amino Acid, Peptide, or Protein; Enzyme ;
=alcohol oxidoreductase;
| - 28. EC 2.7.1.1
- [Expressed in human heart, skeletal muscle, and adipose tissue and encoded by insulin-responsive HK2 Gene (Hexokinase Family), outer mitochondrial membrane-bound 917-amino acid 102-kD monomeric Hexokinase 2 promotes glycolysis. HK2 contains glucose- and ATP-binding sites and a hexokinase domain. The C-terminus contains catalytic activity; membrane binding and regulation associate with the N-terminus. Allosterically regulated by product, HK2 converts aldo-/keto-hexoses to hexose-6-phosphate, the first step of many metabolic pathways. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )] (UMLS (NCI) C0019475) =Amino Acid, Peptide, or Protein; Enzyme ;
|
- 2. EC 1.1.1.27
- [do not confuse with EC 1.1.2.3, EC 1.1.2.4, or EC 1.1.2.5, lactate dehydrogenase (cytochrome). ( CSP )] (UMLS (NCI) C0022917) =Amino Acid, Peptide, or Protein; Enzyme =alcohol oxidoreductase;
| - 29. EC 2.7.1.112
- [Kinases that phosphorylate protein tyrosine residues. These kinases play major roles in mitogenic signalling, and can be divided into two subfamilies: receptor tyrosine kinases, that have an extracellular ligand-binding domain, a single transmembrane domain, and an intracellular tyrosine kinase domain; and nonreceptor tyrosine kinases, which are soluble, cytoplasmic kinases. (Dictionary of Cell and Molecular Biology Online) ( NCI )] (UMLS (NCI) C0033681) =Amino Acid, Peptide, or Protein; Enzyme ;
=EC 2.7.1.37;
=JAK kinase ◊ [LCK is a lymphoid-specific SRC family tyrosine kinase critical for T-cell development and activation. LCK is quickly activated after mIg cross-linking on B-cells or after TCR cross-linking on T-cells and is associated with the cytoplasmic domains of CD4, CD8, and the IL-2R beta chain. LCK may be involved in the earliest steps of TCR-mediated T-cell activation. After antigen binding to the TCR, in concert with co-receptors (CD4, MHC II, CD28, B7, CD8, and MHC I) activation of at least three protein-tyrosine kinases occur, including p59(FYN), p56(LCK), and ZAP70. The pre-TCR co-localizes with LCK into glycolipid rafts, resulting in the phosphorylation of CD3-epsilon and ZAP70. STAT5 is phosphorylated upon TCR stimulation. LCK activates the DNA binding of STAT5A and STAT5B to STAT-inducible elements, which regulate gene transcription and T-cell proliferation during immunologic responses. (from OMIM 153390 and NCI) ( NCI )] (UMLS (NCI) C0065344) Amino Acid, Peptide, or Protein; Enzyme ; |
- 3. EC 1.1.1.49
- [Encoded as 2 alternative isoforms by human housekeeping G6PD Gene (G6PD Family), 514-/560-aa 59-kDa homodimeric or homotetrameric cytosolic Glucose-6-Phosphate Dehydrogenase mainly produces NADPH, an electron donor to oxidizing agents and in biosynthetic reactions. G6PD deficiency may cause jaundice, hemolysis, or non-spherocytic hemolytic anemia. (NCI) ( NCI )] (UMLS (NCI) C0017757) =Amino Acid, Peptide, or Protein; Enzyme ;
=alcohol oxidoreductase;
| - 30. EC 2.7.1.112
- [Expressed in brain, kidney, testis, and widely in fetal tissues by human FGFR3 Gene (FGFR Family), 3 alternative isoforms of highly conserved type I membrane protein Fibroblast Growth Factor Receptor 3, consisting of an acidic- and basic-FGF binding extracellular region (containing 3 Ig C2-type domains), a transmembrane segment, and a cytoplasmic tyrosine kinase domain, activate downstream signal cascades involved in mitogenesis and differentiation, as well as bone development and maintenance. FGFR3 defects cause achondroplasia, crouzon syndrome, thanatophoric dysplasia, coronal synostosis, hypochondroplasia, bladder and cervix cancers. (NCI) ( NCI )] (UMLS (NCI) C0117718) More…
|
- 4. EC 1.1.3.22
- [an iron-molybdenum flavoprotein containing flavin-adenine dinucleotide that oxidizes hypoxanthine, some other purines and pterins, and aldehydes deficiency of the enzyme, an autosomal recessive trait, causes xanthinuria. ( CSP )] (UMLS (NCI) C0043317) =Amino Acid, Peptide, or Protein; Enzyme ;
=alcohol oxidoreductase;
iron sulfur protein | - 31. EC 2.7.1.112
- [Eph-related receptor tyrosine kinase B1; may have a role in neurogenesis (Proteome Summary, from LocusLink) ( NCI )] (UMLS (NCI) C0907648) ELK;
EPH Tyrosine Kinase 2;
EphB1;
EphB1 Protein;
Ephrin Receptor EphB1;
Ephrin Type-B Receptor 1;
HEK6;
NET;
Neuronally Expressed Eph-Related Tyrosine Kinase;
Tyrosine-Protein Kinase Receptor EPH-2 =Amino Acid, Peptide, or Protein; Enzyme; Receptor ◊ [This protein functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. (LocusLink) ( NCI )] (UMLS (NCI) C0915156) EPH- and ELK-Related Tyrosine Kinase; EphA8; EphA8 Protein; EPH-and ELK-Related Kinase; Ephrin Receptor EphA8; Ephrin Type-A Receptor 8; Ephrin Type-A Receptor 8 Precursor; HEK3; Hydroxyaryl-Protein Kinase; Protein Tyrosine Kinase EEK; Protein-Tyrosine Kinase; Tyrosine-Protein Kinase Receptor EEK; Tyrosylprotein Kinase; Amino Acid, Peptide, or Protein; Enzyme; Receptor |
- 5. EC 1.11.1.8
- [Human thyroid peroxidase protein (933 aa, ~103 kDa isoform) is encoded by the human thyroid peroxidase (TPO) gene. This protein is the primary enzyme involved in thyroid hormone synthesis. ( NCI )] (UMLS (NCI) C0021965) =Amino Acid, Peptide, or Protein; Enzyme ;
=peroxidase;
| - 32. EC 2.7.1.112
- [Eph-related receptor tyrosine kinase A4. Semms to have a function in axon guiding and development of the corticospinal tract. (LocusLink and OMIM) ( NCI )] (UMLS (NCI) C1333408) EPHA4;
EPH-Related Receptor Tyrosine Kinase A4;
Ephrin Receptor EphA4;
Ephrin Type-A Receptor 4;
Hek8;
Receptor Protein-Tyrosine Kinase HEK8;
TYRO1 Protein Tyrosine Kinase;
Tyrosine-Protein Kinase Receptor SEK =Amino Acid, Peptide, or Protein; Enzyme; Receptor ◊ [Eph-related receptor tyrosine kinase B3; may have a role in cell migration in the gut. ( NCI )] (UMLS (NCI) C1333409) EphB3; EphB3 Protein; EPH-Like Tyrosine Kinase 2; EPH-Like Tyrosine Kinase-2; Ephrin Receptor EphB3; Ephrin Type-B Receptor 3; Human Embryo Kinase 2; Tyrosine-Protein Kinase Receptor HEK-2 Amino Acid, Peptide, or Protein; Enzyme; Receptor ◊ [EphA2 is overexpressed in many cancers, including 40% of breast cancers. EphA2 can also transform breast epithelial cells in vitro to display properties commonly associated with the development of metastasis. (from Microsc Res Tech 2002 Oct 1;59(1):58-67) ( NCI )] (UMLS (NCI) C1333410) EPHA2; Ephrin Receptor Epha2; Ephrin Type-A Receptor 2; Epithelial Cell Kinase; Epithelial Cell Receptor Protein Tyrosine Kinase; Epithelial Cell Receptor Protein-Tyrosine Kinase; Tyrosine-Protein Kinase Receptor ECK; Amino Acid, Peptide, or Protein; Enzyme; Receptor |
- 6. EC 1.14.13.39
- [Expressed in various cell types, Nitric Oxide Synthases (NOS Family) are constitutive or inducible calcium/calmodulin stimulated homodimers stabilized by BH4 that bind FAD and FMN cofactors, generally contain a flavodoxin-like domain, and synthesize reactive free radical nitric oxide messenger from L-arginine. NO can act as a neurotransmitter and has antimicrobial and antitumoral activities in macrophages. IL12 requires NOS to stimulate tyrosine-phosphorylation of STAT4 by TYK2 in NK cytotoxicity. Vascular NO (endothelia) inhibits muscle contraction through a cGMP pathway, inhibits platelet aggregation, and mediates VEGF-induced angiogenesis. Endothelial AKT phosphorylates and enhances NOS activity. Potentially influencing energy balance, NO can trigger cGMP-dependent mitochondrial biogenesis mediated by induction of the master regulator PPARGC1. (NCI) ( NCI )] (UMLS (NCI) C0132555) =Amino Acid, Peptide, or Protein; Enzyme =Oxygenase;
| - 33. EC 2.7.1.112
- [Leukocyte Tyrosine Kinase is encoded by the human LTK gene. A set of cDNAs represents differently spliced human LTK mRNAs. These cDNAs predict a truncated receptor protein lacking the tyrosine kinase domain and a soluble receptor protein that has neither a transmembrane nor a tyrosine kinase domain. The LTK gene produces not only the putative receptor tyrosine kinase for unknown ligand but also multiple protein products that may have different functions. (from OMIM) ( NCI )] (UMLS (NCI) C1334392) Leukocyte Tyrosine Kinase;
Leukocyte Tyrosine Kinase Receptor;
LTK;
Protein Tyrosine Kinase-1 =Amino Acid, Peptide, or Protein; Enzyme; Receptor |
- 7. EC 1.15.1.1
- [Human superoxide dismutase [Cu-Zn] protein (153 aa, approximately 16 kD) is encoded by the SOD1 gene. This soluble, cytosolic protein acts as a homodimer that catalyzes the disproportionation of two superoxide radicals to yield molecular oxygen and hydrogen peroxide. Certain point mutations in the SOD1 gene produce misfolding of the protein product, resulting in reduced catalytic activity relative to the wild-type protein. This dysfunction has been shown to cause the development of amyotrophic lateral sclerosis. ( NCI )] (UMLS (NCI) C0010461) =Amino Acid, Peptide, or Protein; Enzyme ;
| - 34. EC 2.7.1.112
- [EPH tyrosine kinase 1 is a member of the largest subfamily of RTKs. EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. EPH-family receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and two fibronectin type III repeats. EPH receptors are divided into two groups based on their extracellular domain sequences and affinities for ephrin-A (EPHA) and ephrin-B ligands (EPHB). Ephrin-A2 forms a stable complex with the metalloproteinase Kuzbanian, involving interactions outside the cleavage region and the protease domain. EPH tyrosine kinase 1 receptor binding triggers ephrin-A2 cleavage in a localized reaction specific to the cognate ligand. (from OMIM 179610 and NCI) ( NCI )] (UMLS (NCI) C1370509) EPH Tyrosine Kinase 1;
EPHA1;
Ephrin Receptor EphA1;
Ephrin Type-A Receptor 1;
Erythropoietin-Producing Hepatoma Amplified Sequence;
Receptor Tyrosine Kinase EPH;
Tyrosine-Protein Kinase Receptor EPH =Amino Acid, Peptide, or Protein; Enzyme; Receptor ◊ [Receptor for vegf or vegf-c. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. (from SwissProt) ( NCI )] (UMLS (NCI) C1504624) KDR; Kinase Insert Domain Receptor; Kinase Insert Domain Receptor (A Type III Receptor Tyrosine Kinase); Protein-Tyrosine Kinase Receptor Flk-1; Vascular Endothelial Growth Factor Receptor 2; VEGFR-2 Amino Acid, Peptide, or Protein; Enzyme; Receptor |
- 8. EC 1.17.4.-
- [interconverts ribonucleotides (RNA precursors) and deoxyribonucleotides (DNA precursors) rate limiting to DNA replication in rapidly dividing cells, and therefore a potential target of antineoplastic drugs. ( CSP )] (UMLS (NCI) C0035547) =Amino Acid, Peptide, or Protein; Enzyme ;
=iron sulfur protein;
dehydrogenase | - 35. EC 2.7.1.117
- [mediates calcium-calmodulin dependent phosphorylation of myosin light chain (20 kD) subunits to initiate smooth muscle and other actomyosin based cellular contractility systems inactivated by cyclic AMP dependent protein kinase, accounting for relaxant effect of cAMP. ( CSP )] (UMLS (NCI) C0027120) =Amino Acid, Peptide, or Protein; Enzyme =alcohol phosphotransferase;
|
- 9. EC 1.17.4.1
- [Ribonucleoside-Diphosphate Reductase M2 Chain, encoded by the RRM2 gene, is a subunit of ribonucleoside-diphosphate reductase, a heterodimeric cytoplasmic enzyme essential in dividing cells that reduces ribonucleotides to deoxyribonucleotide precursors for DNA synthesis in S phase. Enzyme activity closely correlates with the cellular rate of growth and appears to vary with the cell cycle. A substrate specificity site and a catalytic activity site regulate enzyme activity. A substrate-binding catalytic site on M1 is only formed in the presence of M2. Synthesis of M2 is regulated in a cell-cycle dependent fashion. Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as M2 subunits. RRM2 gene amplification from a homogeneous staining chromosome region and altered transcription regulation is associated with drug resistance. (From LocusLink and NCI) ( NCI )] (UMLS (NCI) C0297817) =Amino Acid, Peptide, or Protein; Enzyme
| - 36. EC 2.7.1.153
- [Phosphoinositide-3-Kinase, Catalytic, Beta Polypeptide, encoded by the PIK3CB gene, belongs to the PI3/PI4-kinase family. Phosphatidylinositol 3 Kinase is a heterodimer of a P110 (catalytic) and a P85 (regulatory) subunit. It phosphorylates PTDINS, PTDINS4P and PTDINS(4,5)P2 with a preference for PTDINS(4,5)P2. (from Swiss-Prot) ( NCI )] (UMLS (NCI) C1368105) p110-Beta;
Phosphatidylinositol 3-Kinase, Catalytic, 110-kD, Beta;
Phosphatidylinositol 3-Kinase, Catalytic, Beta;
Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit, Beta Isoform;
Phosphoinositide-3-Kinase Catalytic Beta Polypeptide;
PI3K;
PI3KBeta;
PI3-Kinase p110 Subunit Beta;
PIK3CB;
PtdIns-3-Kinase p110 =Amino Acid, Peptide, or Protein; Enzyme ◊ [Phosphoinositide-3-Kinase, Catalytic, Alpha Polypeptide, encoded by the PIK3CA gene, belongs to the PI3/PI4-kinase family. Phosphatidylinositol 3 Kinase is a heterodimer of a P110 (catalytic) and a P85 (regulatory) subunit. It phosphorylates PTDINS, PTDINS4P and PTDINS(4,5)P2 with a preference for PTDINS(4,5)P2. (from Swiss-Prot) ( NCI )] (UMLS (NCI) C1451005) p110-Alpha; Phosphatidylinositol 3-Kinase, Catalytic, 110-kD, Alpha; Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit, Alpha Isoform; Phosphoinositide-3-Kinase Catalytic Alpha Polypeptide; PI3K; PI3-Kinase P110 Subunit Alpha; PIK3CA; PtdIns-3-Kinase p110 Amino Acid, Peptide, or Protein; Enzyme ; |
- 10. EC 1.4.3.13
- [Lysyl oxidase; a copper-dependent enzyme that initiates the crosslinking of collagens and elastin, oxidizes lysine residues to alpha-aminoadipic-delta-semialdehyde. (LocusLink) ( NCI )] (UMLS (NCI) C0024375) =Amino Acid, Peptide, or Protein; Enzyme ;
| - 37. EC 2.7.1.21
- [Human Thymidine Kinases (Thymidine Kinase Family) catalyze thymidine phosphorylation via ATP to deoxythymidine monophosphate. (NCI) ( NCI )] (UMLS (NCI) C0040078) =Amino Acid, Peptide, or Protein; Enzyme ;
=alcohol phosphotransferase;
|
- 11. EC 2
- [enzymes which transfer a group from one compound to another compound. ( CSP )] (UMLS (NCI) C0040676) =Amino Acid, Peptide, or Protein; Enzyme =enzyme;
=Acetyltransferase;
carnitine O palmitoyltransferase;
EC 2.7;
EC 2.4;
transaldolase/transketolase;
alkyltransferase;
nitrogenous group transferase;
sulfur group transferase;
1 carbon transferase;
EC 2.1.1;
| - 38. EC 2.7.1.37
- [group of enzymes under review by NC-IUBMB include EC 2.7.1.38, EC 2.7.1.70, EC 2.7.1.99, EC 2.7.1.109, EC 2.7.1.110, EC 2.7.1.111, EC 2.7.1.115, EC 2.7. 1.116, EC 2.7.1.124, EC 2.7.1.135, and EC 2.7.1.141. ( CSP )] (UMLS (NCI) C0033640) =Amino Acid, Peptide, or Protein; Enzyme ;
=alcohol phosphotransferase;
=dephosphophosphorylase kinase;
EC 2.7.1.112;
EC 2.7.1.37;
CDK;
CDK-Interacting Protein 1;
mammalian target of rapamycin;
calmodulin dependent protein kinase;
G protein coupled receptor kinase;
|
- 12. EC 2.1.1
- [A class of enzymes that transfers a functional methyl group from one chemical compound to another. ( NCI )] (UMLS (NCI) C0025831) =Amino Acid, Peptide, or Protein; Enzyme ;
=EC 2;
1 carbon transferase =catechol methyltransferase;
dTMP Synthase;
AGT;
EC 2.1.1.67;
| - 39. EC 2.7.1.37
- [group of enzymes that catalyze the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors. ( CSP )] (UMLS (NCI) C0072402) =Amino Acid, Peptide, or Protein; Enzyme ;
=EC 2.7.1.37;
|
- 13. EC 2.1.1.31-36
- [Enzymes that catalyze the S-adenosyl-L-methionine-dependent methylation of ribonucleotide bases within a transfer RNA molecule. EC 2.1.1. ( MSH )] (UMLS (NCI) C0035727) =Amino Acid, Peptide, or Protein; Enzyme ;
| - 40. EC 2.7.1.37
- [This protein belongs to the Ser/Thr protein kinase family, CDC2/CDKX subfamily' GSK-3 subsubfamily and is implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN (by similarity). GSK3alpha is a potential regulator of platelet function. ( NCI )] (UMLS (NCI) C0244987) =Amino Acid, Peptide, or Protein; Enzyme ;
|
- 14. EC 2.1.1.67
- [Thiopurine S-methyltransferase catalyzes S-methylation of thiopurine drugs such as 6-mercaptopurine. (locusLink) ( NCI )] (UMLS (NCI) C1336737) Thiopurine methyltransferase;
Thiopurine Methyltransferase (TPMT);
Thiopurine S-Methyltransferase;
TPMT;
=Amino Acid, Peptide, or Protein; Enzyme =EC 2.1.1;
Enzymatic Pathway of Metabolism | - 41. EC 2.7.1.37
- [LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is likely to be a component of an intracellular signaling pathway and may be involved in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Two splice variants have been identified. (LocusLink) ( NCI )] (UMLS (NCI) C0294209) =Amino Acid, Peptide, or Protein; Enzyme ;
|
- 15. EC 2.3.1.48
- [Class of enzymes that catalyze the acetylation of specific lysine residues of histones, proteins that organize eukaryotic DNA into chromatin. Among the proteins that exhibit histone acetyltransferase activity are various transcription factor coactivators. E.C. 2.3.1.48. ( NCI )] (UMLS (NCI) C0062773) =Amino Acid, Peptide, or Protein; Enzyme ;
| - 42. EC 2.7.1.67
- [Phosphoinositide-4-Kinase, Catalytic, Beta Polypeptide, encoded by the PIK4CB gene, belongs to the PI3/PI4-kinase family. This protein phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). It may regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Its enzymatic activity is inhibited by wortmannin. This protein is found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum, and recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-biphosphate (PIP2) on the Golgi complex. Two named isoforms exist resulting from alternative splicing. (from Swiss-Prot) ( NCI )] (UMLS (NCI) C0089793) =Amino Acid, Peptide, or Protein; Enzyme
|
- 16. EC 2.3.1.85
- [animal enzyme is a multi-functional protein catalyzing the reactions of EC 2.3.1.38, EC 2.3.1.39, EC 2.3.1.41, EC 1.1.1.100, EC 4.2.1.61, EC 1.3.1.10, and EC 3.1.2.14. ( CSP )] (UMLS (NCI) C0015683) =Amino Acid, Peptide, or Protein; Enzyme ;
=Acetyltransferase;
=ACP;
| - 43. EC 2.7.2-
- [nonEC; family of protein kinases; mediate intracellular phosphorylation events that link receptor activation to the control of cell proliferation and differentiation. ( CSP )] (UMLS (NCI) C0752312) ERK;
Extracellular Signal-Regulated Kinases;
MAP kinase;
MAPK;
mitogen activated protein kinase;
Mitogen-Activated Protein Kinase;
=Amino Acid, Peptide, or Protein; Enzyme =alcohol phosphotransferase;
|
- 17. EC 2.3.1.97
- [Dioxins are potent mammalian carcinogens and toxins affecting liver, skin, and immune and reproductive systems. N-myristoyltransferase 2 (NMT2) is one of the later dioxin-inducible genes. NMT2 and induced protein myristoyltransferase activity are direct responses to carcinogen exposure. Because inappropriate protein NH(2)-terminal myristoylation appears to play a role in carcinogenesis, induction of NMT2 may play a central role in dioxin carcinogenicity. (from Cancer Res 2001;61:8534-9) ( NCI )] (UMLS (NCI) C1334858) Glycylpeptide N-Tetradecanoyltransferase 2;
NMT2;
N-Myristoyltransferase 2 =Amino Acid, Peptide, or Protein; Enzyme | - 44. EC 2.7.4.6
- [Human nucleoside diphosphate kinase A protein (152 aa, ~17 kD) is encoded by the human NME1 gene. This protein is localized in both the nucleus and the cytoplasm and plays a major role in the synthesis of nucleoside triphosphates other than ATP. This protein is also known to be present in reduced amounts in tumor cells of high metastatic potential. ( NCI )] (UMLS (NCI) C0068895) =Amino Acid, Peptide, or Protein; Biologically Active Substance
|
- 18. EC 2.4
- [transfers glycosyl groups. ( CSP )] (UMLS (NCI) C0085249) =Amino Acid, Peptide, or Protein; Enzyme ;
=EC 2;
=hexosyltransferase;
pentosyltransferase;
sialyltransferase | - 45. EC 2.7.7
- [nucleotidyltransferases. Enzymes (EC class 2.7.7) transferring nucleotide residues (nucleotidyls) from nucleoside di- or triphosphates into dimer or polymer forms. Some nucleotidyltransferases bear specific names (e.g., adenylyltransferases), or trivial names indicating the linkage hydrolyzed in the synthesis (pyrophosphorylases, phosphorylases), or names of the material synthesized (RNA or DNA polymerase). ( NCI )] (UMLS (NCI) C0028632) =Amino Acid, Peptide, or Protein; Enzyme =EC 2.7;
=DNA directed DNA polymerase;
UTP hexose 1 phosphate uridylyltransferase;
polynucleotide phosphorylase;
EC 2.7.7.49;
DNA directed RNA polymerase;
DNA primase;
recombinase;
telomerase;
replicase |
- 19. EC 2.4.2.1
- [The enzyme purine nucleoside phosphorylase belongs to the PNP/MTAP phosphorylase family and together with adenosine deaminase (ADA) serves a key role in purine catabolism, referred to as the salvage pathway. Defects in NP are the cause of nucleoside phosphorylase deficiency (NP deficiency). It leads to a severe T-cell immunodeficiency with neurologic disorder in children. ( NCI )] (UMLS (NCI) C0034135) =Amino Acid, Peptide, or Protein; Enzyme ;
=pentosyltransferase;
| - 46. EC 2.7.7.48
- [An enzyme that catalyzes the template-directed addition of ribonucleotides to the 3' end of a growing RNA chain. The enzyme utilizes single-stranded RNA as a template. ( NCI )] (UMLS (NCI) C0035685) =Amino Acid, Peptide, or Protein; Enzyme
|
- 20. EC 2.4.2.4
- [Endothelial Cell Growth Factor 1 (Platelet-Derived), encoded by the human ECGF1 gene, catalyses the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. This protein may have a role in maintaining the integrity of the blood vessels. It promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. ECGF1 has a highly restricted target cell specificity acting only on endothelial cells. It also limits glial cell proliferation as gliostatin. Defects in ECGF1 are the cause of mitochondrial neurogastrointestinal encephalomyopathy (MNGIE), an autosomal recessive human disease associated with multiple deletions of skeletal muscle mitochondrial DNA (MTDNA). (From LocusLink, Swiss-Prot and NCI) ( NCI )] (UMLS (NCI) C0040083) =Amino Acid, Peptide, or Protein; Enzyme ;
| - 47. EC 2.7.7.49
- [RNA-dependent DNA polymerase. Enzyme involved in the replication of retroviruses, synthesizing a DNA viral intermediate that is then integrated into the host genome as a provirus. ( NCI )] (UMLS (NCI) C0035379) =Amino Acid, Peptide, or Protein; Enzyme =EC 2.7.7;
|
- 21. EC 2.4.2.8
- [Cytoplasmic Hypoxanthine Phosphoribosyltransferases (Purine/Pyrimidine Phosphoribosyltransferase Family) catalyze the conversion of 5-phosphoribosyl-1-pyrophosphate and hypoxanthine, guanine, or 6-mercaptopurine to the corresponding 5'-mononucleotides and pyrophosphate. The enzyme is important in purine biosynthesis as well as central nervous system functions. (NCI) ( NCI )] (UMLS (NCI) C0020687) =Amino Acid, Peptide, or Protein; Enzyme =pentosyltransferase;
| - 48. EC 2.8.2
- [Enzymes that catalyze the transfer of a sulfate group from 3'-phosphoadenylyl sulfate (active sulfate) to the hydroxyl group of an acceptor, which produces the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. The enzymes are also involved in both the posttranslational sulfation of proteins and sulfate conjugation of exogenous chemicals and bile acids. ( NCI )] (UMLS (NCI) C0038769) =Amino Acid, Peptide, or Protein; Enzyme =sulfur group transferase;
|
- 22. EC 2.5.1.18
- [A class of enzymes that catalyze the reaction of glutathione with an acceptor molecule (an arene oxide) to form an S-substituted glutathione; a key step in detoxification of many substances; start of the mercapturic acid pathway. ( NCI )] (UMLS (NCI) C0017837) =Amino Acid, Peptide, or Protein; Enzyme ;
=alkyltransferase;
Enzymatic Pathway of Metabolism | - 49. EC 3.1.1.4
- [Various types of calcium-dependent or -independent Phospholipases A2 hydrolyze phospholipids. Group I, II, and III phospholipases are secreted, while group IV phospholipases are cytosolic. The best characterized phospholipases are group II. (NCI) ( NCI )] (UMLS (NCI) C0031667) =Amino Acid, Peptide, or Protein; Enzyme =carboxylesterase;
|
- 23. EC 2.7
- [Encoded by Kinase Family Genes, Kinase enzymes covalently transfer the terminal, gamma phosphate group from ATP to a variety of substrates and typically play key regulatory roles in diverse cellular functions. (NCI) ( NCI )] (UMLS (NCI) C0031727) =Amino Acid, Peptide, or Protein; Enzyme ;
=EC 2;
=adenylate kinase;
cAMP-Dependent Protein Kinase;
cGMP dependent protein kinase;
EC 2.7.7;
alcohol phosphotransferase;
other phosphotransferase;
JUN kinase;
| - 50. EC 3.3.2.3
- [Expression of microsomal epoxide hydrolase (mEH), a carcinogen-activating enzyme, in primary breast tumors may predict poor response to tamoxifen treatment. (from J Clin Oncol 2001;19:3-9 via Medscape) ( NCI )] (UMLS (NCI) C0026027) =Amino Acid, Peptide, or Protein; Enzyme
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- 24. EC 2.7.1.-
- [PCTAIRE Protein Kinase 1, encoded by the PCTK1 gene, belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. This protein may play a role in signal transduction cascades in terminally differentiated cells. The PCTK1 gene is thought to escape X inactivation. There are three alternatively spliced transcript variants described for this gene. (from LocusLink) ( NCI )] (UMLS (NCI) C0259367) =Amino Acid, Peptide, or Protein; Enzyme
| - 51. EC 3.4.21.35
- [Initial studies indicate that hK2 may be better than PSA as a marker of poorly differentiated prostate cancer tumors ( NCI )] (UMLS (NCI) C0618743) =Amino Acid, Peptide, or Protein; Enzyme ;
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- 25. EC 2.7.1.-
- [G Protein-Coupled Receptor Kinase 7, encoded by the GPRK7 gene, belongs to the GPRK subfamily of the Ser/Thr family of protein kinases. This membrane-bound protein phosphorylates cone opsins, thereby initiating their deactivation in color vision. (from Swiss-Prot) ( NCI )] (UMLS (NCI) C0673406) =Amino Acid, Peptide, or Protein; Enzyme
| - 52. EC 3.4.21.7
- [precursor of fibrinolysin (plasmin); a beta-globulin found mostly in association with fibrinogen in plasma; plasminogen activators change it to fibrinolysin. ( CSP )] (UMLS (NCI) C0032140) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Biologically Active Substance =proenzyme;
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- 26. EC 2.7.1.-
- [G Protein-Coupled Receptor Kinase 2-Like, encoded by the GPRK2L gene, belongs to the Ser/Thr family of protein kinases. It specifically phosphorylates the activated forms of G protein-coupled receptors. Four named alternative splicing forms exist. Isoform 1 can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. (from Swiss-Prot) ( NCI )] (UMLS (NCI) C1333735) G Protein-Coupled Receptor Kinase 2 (Drosophila)-Like;
G Protein-Coupled Receptor Kinase 2-Like;
G Protein-Coupled Receptor Kinase GRK4;
G Protein-Dependent Receptor Kinase 4;
GPRK2L;
ITI1 =Amino Acid, Peptide, or Protein; Enzyme ◊ [G protein-coupled receptor kinases regulate G protein-coupled receptors through phosphorylation. ( NCI )] (UMLS (NCI) C1333738) G Protein-Coupled Receptor Kinase Family; Amino Acid, Peptide, or Protein; Enzyme | - 53. EC 6.1.1.1
- [Encoded by human YARS Gene, the 528-amino acid Tyrosyl-tRNA Synthetase polypeptide belongs to the Class-I Aminoacyl-tRNA Synthetase Family. Likely to be among the first proteins to appear in evolution, amino acyl-tRNA synthetases catalyze tRNA amino acylation by their cognate amino acid. Under apoptotic conditions, tyrosyl-tRNA synthetase may be secreted and cleaved into an N-terminal IL8-like cytokine fragment that harbors the catalytic site and a C-terminal EMAP II-like cytokine fragment. (OMIM, Swiss-Prot, LocusLink, and NCI) ( NCI )] (UMLS (NCI) C0041497) =Amino Acid, Peptide, or Protein; Enzyme ;
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- 27. EC 2.7.1.-
- [p21-Activated Kinase 6, encoded by the PAK6 gene, shares a high degree of sequence similarity with p21-activated kinase (PAK) family members. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. p21-Activated Kinase 6 was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. The PAK6 gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to cotranslocate into the nucleus with AR in response to androgen. (from LocusLink) ( NCI )] (UMLS (NCI) C1337052) p21(CDKN1A)-Activated Kinase 6;
p21-Activated Kinase 6;
p21-Activated Protein Kinase 6;
PAK-5;
PAK6;
PAK-6;
Serine/Threonine-Protein Kinase PAK 6 =Amino Acid, Peptide, or Protein; Enzyme ;
| - 54. EC 6.3.2.2
- [Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. The gene encoding the catalytic subunit encodes a protein of 367 amino acids with a calculated molecular weight of 72.773 kDa and maps to chromosome 6. The regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Deficiency of gamma-glutamylcysteine synthetase in human is associated with enzymopathic hemolytic anemia. (LocusLink) ( NCI )] (UMLS (NCI) C0017037) =Amino Acid, Peptide, or Protein; Enzyme
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