[Expressed in human heart, skeletal muscle, and adipose tissue and encoded by insulin-responsive HK2 Gene (Hexokinase Family), outer mitochondrial membrane-bound 917-amino acid 102-kD monomeric Hexokinase 2 promotes glycolysis. HK2 contains glucose- and ATP-binding sites and a hexokinase domain. The C-terminus contains catalytic activity; membrane binding and regulation associate with the N-terminus. Allosterically regulated by product, HK2 converts aldo-/keto-hexoses to hexose-6-phosphate, the first step of many metabolic pathways. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )]
UMLS (NCI) C0019475 - Amino Acid, Peptide, or Protein
- Enzyme
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