UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
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1. AZD6474
[An orally bioavailable 4-anilinoquinazoline. ZD-6474 selectively inhibits the tyrosine kinase activity of vascular endothelial growth factor receptor 2 (VEGF2), thereby blocking VEGF-stimulated endothelial cell proliferation and migration and reducing tumor vessel permeability. This agent also blocks the tyrosine kinase activity of epidermal growth factor receptor (EGFR), a receptor tyrosine kinase that mediates tumor cell proliferation and migration and angiogenesis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=269177&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=269177&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2737" NCI Thesaurus) ( PDQ )] (UMLS (NCI) C1384659) ZD6474;
ZD-6474;
=Organic Chemical; Pharmacologic Substance

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