- 1. ARHB
- [RHO B protein is a GTP-binding protein involved in a signal transduction pathway that controls assembly of focal adhesions and actin stress fibers. Rho regulates remodeling of the actin cytoskeleton during cell morphogenesis and motility. Active Rho signals to its downstream effector ROCK1, which phosphorylates and activates LIM kinase. LIM kinase, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. (from OMIM 165370 and NCI) ( NCI )] (UMLS (NCI) C0073186) =Amino Acid, Peptide, or Protein; Enzyme ;
| - 5. ARHGEF5
- [Oncogene TIM encodes a predicted 60 kD protein containing a DBL homology domain, shared by several signal transducing regulators of small GTP-binding proteins. TIM is thought to control cytoskeletal organization through regulation of small GTP-binding proteins. The human gene is located at 7q33-q35. ( NCI )] (UMLS (NCI) C1332111) ARHGEF5 Gene;
Guanine nucleotide regulatory protein TIM gene;
Oncogene TIM;
Rho Guanine Nucleotide Exchange Factor (GEF) 5 Gene;
Rho guanine nucleotide exchange factor 5 gene;
Transforming immortalized mammary oncogene =Gene or Genome ;
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- 2. ARHGEF1
- [Ubiquitously expressed by human ARHGEF1 Gene as alternative isoforms 1 (912-aa, 102-kD) and 2 (879-aa), cytoplasmic Rho Guanine Nucleotide Exchange Factor 1 contains a (homooligomerizing) coiled coil region, a DH domain, a PH domain, and an RGSL domain (necessary for GAP activity). Responsive to extracellular stimuli acting through GPCRs, ARHGEF1 may complex with G proteins and regulates cell cycle and cell proliferation activity. Phosphorylated by PKCA and translocated to the plasma membrane by stimulation, ARHGEF1 seems to regulate RHOA GTPase signal transduction as a GEF and GNA12 and GNA13 (RGS domain interaction) as a GAP. ARHGEF1 GEF activity is inhibited by binding to activated GNA12. (NCI) ( NCI )] (UMLS (NCI) C0606872) =Amino Acid, Peptide, or Protein; Biologically Active Substance
| - 6. ARHH
- [Encoded by human oncogene ARHH Gene, the 191-amino acid 21 kD hemopoietic cell RHOH/TTF Protein contains residues associated with binding and hydrolysis of GTP. ARHH belongs to the small GTPase superfamily, RHO family; highest identity is found with RHO-like CDC42 protein. (OMIM, Swiss-Prot, and NCI) ( NCI )] (UMLS (NCI) C1335598) GTP-Binding Protein TTF;
RAS Homolog Gene Family Member H Protein;
RHOH/TTF Protein;
RHO-Related GTP-Binding Protein RHOH;
=Amino Acid, Peptide, or Protein; Enzyme |
- 3. ARHGEF1
- [This gene plays a role in signal transduction and cell cycle control. ( NCI )] (UMLS (NCI) C1332110) ARHGEF1 Gene;
Rho Guanine Nucleotide Exchange Factor (GEF) 1 Gene =Gene or Genome ;
| - 7. ARHI
- [Encoded by human ARHI Gene, the 229-amino acid 26 kD RHO-Related GTP-Binding Protein RHOI (RHO Family) appears to be a tumor suppressor expressed in breast and ovarian epithelial cells, and in heart, liver, pancreas, and brain; expression is absent in breast and ovarian cancer cell lines. Growth factors decrease expression of RHOI Protein, as does WAF1 (CDKN1A). The 229 amino acid protein shares 54% amino acid homology with HRAS and 56-62% homology with RAS-related proteins, and contains a highly conserved GTP-binding domain, a putative effector domain distinct from RAS and RAP proteins, and a C-terminal membrane localization motif. (from SWISS-PROT, OMIM, and NCI) ( NCI )] (UMLS (NCI) C1335619) ARHI Protein;
RAS Homolog Gene Family, Member I Protein;
RAS-Related GTP-Binding Protein Member I Protein;
RHO-Related GTP-Binding Protein RHOI =Amino Acid, Peptide, or Protein; Biologically Active Substance |
- 4. ARHGEF5
- [This is a 60 kD protein containing a Dbl-homology domain, which is shared by several signal transducing molecules implicated as regulators of small GTP-binding proteins. TIM is thought to be involved in control of cytoskeletal organization through regulation of small GTP-binding proteins. (from OMIM 600888 and NCI) ( NCI )] (UMLS (NCI) C0383269) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
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