- 1. AKT
- [Expressed in diverse tissues, Protein Kinase B (AKT/RAC Family) is a group (Alpha, Beta and Gamma) of cytoplasmic serine/threonine enzymes that covalently transfer the terminal, gamma phosphate group from ATP to a variety of substrate proteins and regulate cell signaling responses to insulin, PDGF, and IGF1 (through PI3K) involved in cell survival, cell proliferation, differentiation, apoptosis, glycogen synthesis, and glucose uptake. ( NCI )] (UMLS (NCI) C0164786) =Amino Acid, Peptide, or Protein; Enzyme ;
| - 5. AKT2
- [This gene plays a role in glucose homeostasis and the inhibition of apoptosis. ( NCI )] (UMLS (NCI) C0812230) AKT2 Gene;
v-akt MurineThymoma Viral Oncogene Homolog 2 Gene =Gene or Genome |
- 2. AKT1
- [RAC-Alpha Serine/Threonine Kinase (AKT1) encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. The activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. AKT1 also promotes cell survival and regulates nitric oxide from endothelium, target of the PDGF-activated phosphatidylinositol 3-kinase. (From LocusLink and NCI) ( NCI )] (UMLS (NCI) C0285558) =Amino Acid, Peptide, or Protein; Enzyme ;
| - 6. AKT3
- [Highly expressed in brain, lung, kidney and fetal heart, liver, brain by human AKT3 Gene (AKT/RAC Family) as alternative isoforms 1 (479-aa, 55.8-kD) and 2 (465-aa; shorter C-terminus), cytoplasmic Protein Kinase B Gamma contains a PH domain that binds PI(3)K alpha and promotes plasma membrane translocation after cell stimulation. Fully active when phosphorylated on threonine and serine residues, AKT3 phosphorylates several proteins to regulate cell signaling responses to insulin, PDGF, and IGF1 involved in cell proliferation, differentiation, apoptosis, glycogen synthesis, and glucose uptake. (NCI) ( NCI )] (UMLS (NCI) C0673232) =Amino Acid, Peptide, or Protein; Enzyme
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- 3. AKT1
- [This gene is involved in signal transduction and negative regulation of apoptosis. It also plays a role in glucose transport, glycogen synthesis, protein synthesis and neuronal survival. ( NCI )] (UMLS (NCI) C0812228) AKT1 Gene;
v-akt Murine Thymoma Viral Oncogene Homolog 1 Gene =Gene or Genome | - 7. AKT3
- [This gene is involved in signal transduction and the inhibition of apoptosis. ( NCI )] (UMLS (NCI) C1332074) AKT3 Gene;
v-akt Murine Thymoma Viral Oncogene Homolog 3 (Protein Kinase B, Gamma) Gene;
=Gene or Genome |
- 4. AKT2
- [The AKT2 oncogene encodes RAC-beta protein kinase, belonging to a serine/threonine kinase subfamily containing SH2-like domains. The AKT2 isoform of PI-dependent protein kinase Akt is enriched in insulin-responsive tissues and may function in the metabolic actions of that hormone. Glucose homeostasis depends on insulin responsiveness in target tissues. Insulin induces phosphorylation of scaffolding proteins and activation of PI3-kinase, which activate Akt. A deficiency of Akt2 impairs the ability of insulin to lower blood glucose and may function in the maintenance of normal glucose homeostasis. (from OMIM 164731 and NCI) ( NCI )] (UMLS (NCI) C0166559) =Amino Acid, Peptide, or Protein; Enzyme
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