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UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
%
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
L L L- L0 L1 L6 LA LB LC LD LE LF LG LH LI LK LL LM LN LO LP LR LS LT LU LV LX LY
LI LIA LIB LIC LID LIE LIF LIG LII LIK LIL LIM LIN LIO LIP LIQ LIR LIS LIT LIV LIZ

liposomal lurtotecan

[A liposome-encapsulated formulation of lurtotecan with antineoplastic activity. Lurtotecan, a semisynthetic analogue of camptothecin, selectively stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex during S phase of the cell cycle, thereby inhibiting religation of topoisomerase I-mediated single-stranded DNA breaks. This ultimately results in an inhibition of DNA replication, inducing double-stranded DNA breakages, obstruction of RNA and protein synthesis and triggering apoptosis. Furthermore, this agent also stimulates degradation of topoisomerase I, likely mediated through ubiquitin-proteasomal pathway. Liposomal delivery of lurtotecan improves its penetration and delivery into tumors while lowering systemic side effects. ( NCI )]
UMLS (NCI) C0796638
liposome, lurtotecan
Lurtotecan Liposome
 
Organic Chemical
Pharmacologic Substance


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