A A A+ A- A0 A1 A2 A3 A4 A5 A6 A7 A8 A9 AA AB AC AD AE AF AG AH AI AJ AK AL AM AN AO AP AQ AR AS AT AU AV AW AX AY AZ
aspartate carbamoyltransferase
[Human CAD Gene (DHOase Family) encodes a trifunctional homohexameric cytoplasmic 2225-aa 243-kDa protein associated with the first 3 enzymatic activities of the 6-step de novo pyrimidine nucleotide biosynthesis pathway: Carbamoylphosphate Synthetase (GD-CPSASE), Aspartate Carbamoyltransferase, and Dihydroorotase, containing a CPSase domain and a type-1 glutamine amidotransferase domain. PRPP is a CAD activator and UMP is an inhibitor of CPSase. CAD is directly regulated allosterically by phosphorylation from the MAPK cascade. ( NCI )]
UMLS (CSP) C0004006- Amino Acid, Peptide, or Protein
- Enzyme
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