Yttrium Y 90 -DOTATOC
[A radiotherapeutic containing an octreotide derivative, edotreotide, labeled with yttrium 90 (Y-90) with potential antineoplastic activity. Yttrium Y-90 edotreotide is produced by substituting tyrosine for phenylalanine at the 3 position of octreotide and chelated via dodecanetetraacetic acid (DOTA) to Y-90. Like the somatostatin analogue octreotide, this radioconjugate binds to somatostatin receptors (SSTRs), especially type 2, present on the cell membrane of many types of neuroendocrine tumors, thereby delivering beta emitting nuclide Y-90 to SSTR-positive cells resulting in tissue specific cytotoxicity. ( NCI )]
UMLS (NCI) C1328662Yttrium Y 90-DOTA-Tyr3-Octreotide
Yttrium Y 90-Edotreotide
Yttrium Y 90-Edotreotide
- Amino Acid, Peptide, or Protein
- Pharmacologic Substance
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