[Widely expressed (as alpha, beta, delta, and epsilon isoforms) by human PPP2R4 Gene, Protein Phosphatase 2A Regulatory Subunit PR53 is a specific and reversible phosphotyrosyl phosphatase activator of heterodimeric PP2A core enzyme in the presence of ATP and Mg(+2). Implicated in negative control of cell growth and division, PP2A core enzyme consists of a 36-kDa catalytic C subunit and a constant 65-kDa regulatory/structural A subunit that interact with either a B regulatory subunit or with cell signaling molecules, that likely modulate substrate selectivity, catalytic activity, and subcellular localization, yielding the trimeric holoenzyme. Combinations of different subunit isoforms can generate many forms of PP2A, which may differ in substrate specificity, subcellular localization, or tissue specific expression. (NCI) ( NCI )]
UMLS (NCI) C0255156 - Amino Acid, Peptide, or Protein
- Biologically Active Substance
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