PAP2

[Expressed ubiquitously by human PPAP2A Gene (PAP Family), 284-aa 32-kDa Phosphatidic Acid Phosphatase Type 2A is a type 2 integral plasma membrane glycoprotein enzyme with extracellular activity predicted to contain 6 transmembrane regions and a conserved N-glycosylation site. PPAP2A exhibits 47% sequence identity with PPAP2B and 54% identity with PPAP2C; the C-terminal 40-aa of PPAP2A, PPAP2B, and PPAP2C show greatest divergence. PPAP2A has an active role in metabolic pathways controlling synthesis of glycerophospholipids and triacylglycerols, in hydrolysis and uptake of lipids from the extracellular space, in dephosphorylation of phosphatidic acid to diacylglycerol, and in receptor-activated signal transduction mediated by phospholipase D. (NCI) ( NCI )]

UMLS (NCI) C1335404

PAP2A
Phosphatidic Acid Phosphatase 2A
Phosphatidic Acid Phosphatase Type 2A
Phosphatidic Acid Phosphohydrolase Type 2A
PPAP2A
Type 2 Phosphatidic Acid Phosphohydrolase
Type-2 Phosphatidic Acid Phosphatase Alpha

Amino Acid, Peptide, or Protein
Enzyme

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