Nuclear Mitotic Apparatus Protein 1
[Encoded by human NUMA1 Gene, Nuclear Mitotic Apparatus Protein 1 is a structural component of the nucleus containing the largest known protein coiled-coil region, present throughout the interphase nucleus, and localized to the mitotic spindle apparatus. Required for organizing mitotic spindle poles, NUMA1 also appears to have a role in nuclear reassembly in late mitosis. NUMA C-terminal region specifically interacts with nuclear transport factor Importin-beta, which inhibits microtubule aster assembly. Regulating NUMA/Importin-beta interaction, Ran GTPase stimulates assembly of microtubule asters and spindles. (NCI) ( NCI )]
UMLS (NCI) C1335072NUMA
NUMA1
NUMA1
- Amino Acid, Peptide, or Protein
- Immunologic Factor
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