Lymphoid-Specific OTF 1

[Encoded by human POU2F1 Gene (POU2 Family), ubiquitous transcription factor OTF-1 contains one homeobox domain, binds to the octamer ATTTGCAT motif, and activates genes for some snRNA, histone H2B, and immunoglobulins. POU domain proteins contain a bipartite DNA-binding domain divided by a flexible linker that enables diverse monomeric configurations on DNA; additional versatility is conferred by dimerization. OTF-1 POU dimers on palindromic OCT factor recognition elements, or PORE, (ATTTGAAATGCAAAT) can recruit transcriptional coactivator OBF1. OTF-1 interacts with transcription activators NR3C1, AR, and PGR. (from LocusLink, Swiss-Prot, and NCI) ( NCI )]

UMLS (NCI) C1442824

NF-A1
NF-III
Nuclear Factor III
01.��
Octamer Transcription Factor-1
Octamer-Binding Transcription Factor 1
OTF-1
POU Domain, Class 2, Transcription Factor 1
POU2F1

Amino Acid, Peptide, or Protein
Biologically Active Substance

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