[An orally-active fumarate salt of liarozole, an agent with potential antineoplastic. As a retinoic acid metabolism blocking agent (RAMBA), liarozole fumarate inhibits cytochrome P450 dependent all-trans-retinoic acid (ATRA)-4-hydroxylase, resulting in an increase in endogenous ATRA production, inhibition of cell proliferation, and induction of cell differentiation. This agent also inhibits aromatase, the enzyme that catalyzes the final, rate-limiting step in estrogen biosynthesis. (NCI04) ( NCI )]
UMLS (NCI) C0245820 - Organic Chemical
- Pharmacologic Substance
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