Large Tumor Suppressor 1

[Widely expressed in fetal and adult tissues and encoded by human LATS1 Gene (SER/THR PK Family), conserved putative tumor suppressor Large Tumor Suppressor Homolog 1 is an 1130-amino acid 127-kD Ser/Thr protein kinase cell cycle regulator containing a catalytic domain and an UBA/TS-N domain. The C-terminal kinase domain of human and mouse proteins share 99% identity; human and Drosophila share 74% identity. The kinase domain and N-terminal region interact, suggesting intramolecular regulation. Phosphorylated in a cell cycle-dependent manner (late prophase-metaphase), LATS1 is a negative regulator of CDC2/cyclin A. In early mitosis, it complexes (via the N-terminal region) with the mitotic apparatus cell cycle controller CDC2 kinase; the complex shows reduced H1 histone kinase activity. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )]

UMLS (NCI) C1259016

Large Tumor Suppressor Homolog 1
LATS (Large Tumor Suppressor) Homolog 1
LATS Homolog 1
LATS1
LATS1 Protein