LAMP3

[Expressed in appendix, thymus, lymph node, lung, and spleen and encoded by human LAMP3 Gene (LAMP Family), Lysosomal-Associated Membrane Protein 3 is likely involved in antigen processing by lymphoid dendritic cells that capture antigens, differentiate, and induce T-cell responses. Expression increases in mature interdigitating dendritic cells in T-cell areas. A 416-amino acid 70- to 90-kD type I integral membrane protein (larger than predicted, 44-kD), DCLAMP contains N-and O-glycosylation sites, a LAMP domain, a large extracellular domain, a transmembrane domain, and a 10-amino acid cytoplasmic domain containing a conserved GY lysosomal targeting motif. Expression is up regulated in carcinomas of esophagus, colon, rectum, ureter, stomach, breast, fallopian tube, thyroid, and parotid tissues. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )]

UMLS (NCI) C1308703

LAMP3 Protein
Lysosomal-Associated Membrane Protein 3
Lysosome-Associated Membrane Glycoprotein, Dendritic Cell-Specific
TSC403 Protein