[Expressed in a variety of tissues (muscle highest) by human SSPN Gene, integral membrane protein Sarcospan is a component of the sarcolemma dystrophin-glycoprotein complex (DGC) that spans the muscle plasma membrane and links the F-actin cytoskeleton with the extracellular matrix. Isoform 1 (243-aa, 26.6-kDa) is expressed in heart and skeletal muscle; isoform 2 (132-aa) in heart, skeletal muscle, thymus, prostate, testis, ovary, small intestine, colon, and spleen. SSPN preferentially associates with the DGC sarcoglycan subcomplex and may be found in myotendinous junctions and in postsynaptic membrane of neuromuscular junctions. (NCI) ( NCI )]
UMLS (NCI) C0669134 - Amino Acid, Peptide, or Protein
- Biologically Active Substance