Kinase Suppressor of Ras
[Similar to RAS kinase suppressor (Drosophila) and encoded by human KSR Gene (SER/THR PK Family), Kinase Suppressor of RAS-1 is a positive modulator of RAS-MAP kinase signaling. KSR Homologs are found in C. elegans and mouse. The predicted 873-amino acid mouse protein contains a kinase domain similar to RAF kinases; human protein is nearly 95% similar to mouse. In unstimulated cells, CTAK1 constitutively associates with KSR1, phosphorylating Ser392 and conferring cytoplasmic sequestration by 14-3-3 binding. In response to growth factor, KSR1 Ser392 phosphorylation falls, allowing KSR1 to localize with activated RAS and RAF1 at the plasma membrane and facilitating phosphorylation required for activation of MEK and MAPK. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )]
UMLS (NCI) C1334325Kinase Suppressor of RAS-1
KSR
KSR Protein
KSR
KSR Protein
- Amino Acid, Peptide, or Protein
- Enzyme
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