[Encoded by human KISS1 Gene, the 145-amino acid 15 kD KISS1 Metastasis Suppressor Protein may regulate events downstream of cell-matrix adhesion, perhaps cytoskeletal reorganization. Expressed in placenta, pancreas, and kidney, KISS1 may suppress metastasis without affecting tumorigenicity. Metastin, a placental truncated C-terminally amidated peptide form of KISS1, with 54 amino acid residues, is an endogenous ligand of orphan GPR54 (GPCR) and appears to inhibit chemotaxis and metastasis. (NCI) ( NCI )]
UMLS (NCI) C0540309 - Amino Acid, Peptide, or Protein
- Biologically Active Substance