ERG-Associated Protein with Set Domain

[Widely expressed (high in testis) by human SETDB1 Gene (Suvar3-9 Family) as 2 alternative isoforms, 1291-aa 143-kDa nuclear Histone H3-K9 Methyltransferase 4, excluded from nucleoli and condensed chromatin, methylates histone H3 Lys-9 in epigenetic transcriptional repression that recruits HP1 proteins to methylated histones. SETDB1 contains an MBD domain, a pre-SET, a SET, and a post-SET domain, and 2 Tudor domains; pre-SET, SET and post-SET are required for methyltransferase activity. Isoform 2 lacks all methyltransferase domains. The conserved SET domain is implicated in transcriptional modulation of active or repressed chromatin through remodeling. Targeted to histone by TRIM28/TIF1B, SETDB1 contributes to euchromatic gene silencing by KRAB zinc-finger proteins and may interact with ERG. (NCI) ( NCI )]

UMLS (NCI) C1120304

ESET
H3-K9-HMTase 4
Histone H3-K9 Methyltransferase 4
Histone-Lysine N-Methyltransferase H3 Lysine-9 Specific 4
SET Domain Bifurcated 1
SETDB1