Baculoviral IAP Repeat-Containing Protein 7
[Encoded by BIRC7 Gene, Livin is a potent anti-apoptotic protein and caspase inhibitor with pleiotropic effects on apoptosis induced by various stimuli. BIRC7 anti-apoptotic activity is achieved by two mechanisms: TAK1-dependent JNK1 activation and caspase inhibition. Induced by a death stimulus, processed and activated SMAC interacts with the BIRC7 BIR (baculovirus IAP repeat) domain to abrogate BIRC7 inhibition of apoptosis. Alpha and beta BIRC7 splice variants have different biological properties and tissue distribution, though both have a significant anti-apoptotic activity. (NCI) ( NCI )]
UMLS (NCI) C0964024BIRC7
Kidney Inhibitor of Apoptosis
Livin
Melanoma Inhibitor of Apoptosis
Kidney Inhibitor of Apoptosis
Livin
Melanoma Inhibitor of Apoptosis
- Amino Acid, Peptide, or Protein
- Biologically Active Substance
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