- 1. BAP
- (UMLS (NCI) C0279231) =Therapeutic or Preventive Procedure ;
| - 3. BAP1
- [Encoded by the ubiquitously expressed human BAP1 Gene. The 729-amino acid nuclear BRCA1 Associated Protein-1 contains an acidic region, a highly charged C- terminus, and putative nuclear localization signals. The N-terminus shows homology to ubiquitin C-terminal hydrolases, thiol proteases that catalyze ubiquitin proteolytic processing. BAP1 interacts with the BRCA1 RING finger, but this interaction is prevented by RING finger germline mutations of BRCA1 found in breast cancer kindreds. BAP1 enhances BRCA1-mediated inhibition of breast cancer cell growth, acting as a tumor suppressor in the BRCA1 growth control pathway. (from OMIM) ( NCI )] (UMLS (NCI) C1368335) BRCA1 Associated Protein-1;
Cerebral Protein-13; Cerebral Protein-6; Ubiquitin Carboxy-Terminal Hydrolase =Amino Acid, Peptide, or Protein; Biologically Active Substance |